{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:34:06Z","timestamp":1769873646149,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T00:00:00Z","timestamp":1283385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> <jats:italic>Monascus<\/jats:italic>\u2010fermented products are among the most commonly used traditional food supplements. Dioscorea is known to exhibit anticancer properties. In this study the effects of the ethanol extract of red mold dioscorea (RMDE) on cell proliferation, cell cycle and apoptosis in human oral cancer cells were investigated.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> RMDE exercised growth inhibition on squamous cell carcinoma\u201025 (SCC\u201025) cells. RMDE\u2010mediated G2\/M phase arrest was associated with the down\u2010regulation of NF\u2010\u03baB, resulting in the inhibition of cyclin B1 and CDK1 expression; this may be the mechanism by which RMDE inhibits cancer cells. Furthermore, the proapoptotic activity of RMDE was revealed by the Annexin V\u2010FITC\/PI double\u2010staining assay. In addition, the proapoptotic effect of RMDE was evident by the inhibition of Bax expression in the mitochondria, resulting in the activation of caspase\u20109 and caspase\u20103 and subsequent triggering of the mitochondrial apoptotic pathway. RMDE also enhanced caspase\u20108 activity, indicating the involvement of the death receptor pathway in RMDE\u2010mediated SCC\u201025 cell apoptosis.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> RMDE treatment inhibited the growth of SCC\u201025 cells by arresting cell cycle at the G2\/M phase and induced apoptosis in a time\u2010 and dose\u2010dependent manner. Therefore RMDE may be a good candidate for development as a dietary supplement against oral cancer. 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