{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:19:27Z","timestamp":1768515567393,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> A large number of plants and their isolates have been shown to potentiate immunity. Some plants exert anti\u2010inflammatory and anti\u2010stress effects, others hepatoprotective activity. In this study, 320 1\u2010day\u2010old broiler chicks were randomly divided into four major groups A, B, C and D and fed rations supplemented with 0, 15, 20 and 22.5 g <jats:italic>Berberis lycium<\/jats:italic> kg<jats:sup>\u22121<\/jats:sup> ration respectively. Each group was further divided into two subgroups, one vaccinated against Newcastle disease (ND) and infectious bursal disease (IBD), the other non\u2010vaccinated. Antibody titre against IBD and ND, relative weight of lymphoid organs, post\u2010challenge morbidity and mortality, serum hepatic enzymes and total serum protein were observed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Group C had higher anti\u2010IBD and anti\u2010ND antibody titres. Relative bursa weight in groups C and D was higher until day 28, but birds in group C performed better at later stages of examination. Relative spleen weight was highest in group C. During initial stages there was no effect on relative thymus weight, but at later stages the effect was significant. Groups C and D performed similarly in terms of relative thymus weight. The birds were challenged to field IBD through intramuscular injection at a dose rate of 0.5 mL per bird. Post\u2010challenge morbidity was lowest in groups C and D, while treatment significantly (<jats:italic>P<\/jats:italic> &lt; 0.001) affected mortality amongst affected (morbid) birds. Levels of serum alanine aminotransferase and alkaline phosphatase were lowest in group C. Serum protein was similar in all groups and in both vaccinated and non\u2010vaccinated broiler chicks.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> <jats:italic>Berberis lycium<\/jats:italic> added to feed at 20 g kg<jats:sup>\u22121<\/jats:sup> is effective in improving immunity against ND and IBD as well as liver function in broiler chicks. 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