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Merr. et Perry (Myrtaceae), was investigated for its reversal effects on cancer cell MDR.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> A human hepatocellular tumor xenograft model was established with the BEL\u20107402\/5\u2010FU cell line. Combined 5\u2010fluorouracil (5\u2010FU) and DMC (40 mg kg<jats:sup>\u22121<\/jats:sup>) treatment significantly elevated tumor inhibition rate to 72.2%. DMC could also increase 5\u2010FU concentrations in tumor tissues and increase caspase\u20103 activity. Also, combined therapy resulted in enhanced tumor apoptotic and reduced proliferative activities relative to 5\u2010FU alone. Examining body weight and other signs of unwanted toxicity of the different treatment groups revealed no significant signs of adverse effects.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> All results suggested that DMC reverses 5\u2010FU resistance, with a benign side effects profile. 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