{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:57:15Z","timestamp":1780052235857,"version":"3.53.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:bold>Cassava (<jats:italic>Manihot esculenta<\/jats:italic> Crantz), a plant used as food and an ingredient in industry, contains cyanogenic glycosides. The cassava root contains wastewater, popularly known as <jats:italic>manipueira<\/jats:italic>, which is a toxic substance. Its ingestion by animals causes poisoning although they react positively to treatment with sodium thiosulfate. The present research evaluates the cytotoxicity and the mutagenicity of liquid waste produced in the process of industrialization of the bitter cassava, <jats:italic>olho\u2010junto<\/jats:italic> variety. The liquid wastes are characterized as press water, which is obtained when the cassava roots are pressed; pond water, which is press water stored in impounded ponds; and a solution of sodium thiosulfate, pure and with other waste<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:bold>The system tests comprised root meristematic cells of <jats:italic>Allium cepa<\/jats:italic> L. and bone marrow cells of <jats:italic>Rattus norvegicus<\/jats:italic>. Treatment with saline solution was cytotoxic for <jats:italic>Allium cepa<\/jats:italic> L. and significantly reduced cell division rate. Although no treatment was cytotoxic in any of the tests with rats, the thiosulfate solution was clastogenic for the chromosomal aberrations test<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:bold>Since it is harmful to the genetic material submitted within the conditions of current research, sodium thiosulfate should only be used in emergency conditions in which the benefits exceed the risks. \u00a9 2013 Society of Chemical Industry<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6268","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T14:42:58Z","timestamp":1371480178000},"page":"453-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mutagenicity and cytotoxicity of liquid waste, press water and pond water, produced in the cassava flour industry, and of antitoxic sodium thiosulfate"],"prefix":"10.1002","volume":"94","author":[{"given":"Lilian \u00c1vila","family":"Viana","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Genetics and Cell Biology State University of Maring\u00e1 Avenida Colombo 5790, Bloco H67 (11), Jardim Universit\u00e1rio CEP: 87020\u2010900 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elis\u00e2ngela","family":"D\u00fcsman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Genetics and Cell Biology State University of Maring\u00e1 Avenida Colombo 5790, Bloco H67 (11), Jardim Universit\u00e1rio CEP: 87020\u2010900 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Elisa Pimenta","family":"Vicentini","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Genetics and Cell Biology State University of Maring\u00e1 Avenida Colombo 5790, Bloco H67 (11), Jardim 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