{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:56:29Z","timestamp":1787313389156,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,3,30]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n \n Liriopes Radix, which is regarded as both drug and healthy diet, is drunk as tea and used in traditional Chinese medicine to treat diabetes. Based on our previous studies, investigated the hypoglycemic effects and explored the mechanisms of total polysaccharides from\n Liriope spicata<\/jats:italic>\n var.\n prolifera<\/jats:italic>\n (Liriopes Radix) in a diabetic rat model.\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n \n TLSP<\/jats:styled-content>\n reduced hyperglycemia in diabetic rats. The oral glucose tolerance test showed that\n TLSP<\/jats:styled-content>\n could improve the glucose tolerance of diabetic rats. Damage to liver and pancreas tissue was inhibited after treatment with\n TLSP<\/jats:styled-content>\n . Moreover,\n TLSP<\/jats:styled-content>\n increased glycogen content, glucokinase (\n GK<\/jats:styled-content>\n ) and glycogen synthetase (\n GS<\/jats:styled-content>\n ) activities, and suppressed the elevation of glucose\u20106\u2010phosphatase (\n G6Pase<\/jats:styled-content>\n ) and glycogen phosphorylase (\n GP<\/jats:styled-content>\n ) activities in liver. Compared with the diabetic control group,\n GK<\/jats:styled-content>\n and\n GS mRNA<\/jats:styled-content>\n expression were significantly elevated, while\n G6Pase<\/jats:styled-content>\n and\n GP mRNA<\/jats:styled-content>\n expression were decreased in\n TLSP<\/jats:styled-content>\n groups. In addition,\n TLSP<\/jats:styled-content>\n could inhibit glycogen synthase kinase\u20103\u03b2 expression and increase insulin receptor, insulin receptor substrate\u20101, phosphoinositide 3\u2010kinase, protein kinase B and glucose transport protein\u20104 expression in liver.\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n \n TLSP<\/jats:styled-content>\n showed hypoglycemic function. Improvement of glucose metabolism and insulin\u2010signaling transduction were possible mechanisms. \u00a9 2013 Society of Chemical Industry\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.6347","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T11:20:41Z","timestamp":1376306441000},"page":"975-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Polysaccharides from Liriopes Radix ameliorates hyperglycemia via various potential mechanisms in diabetic rats"],"prefix":"10.1002","volume":"94","author":[{"given":"Zuo\u2010qi","family":"Xiao","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010long","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010ran","family":"Gan","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences Huazhong University of Science and 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