{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:35:08Z","timestamp":1792128908318,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        Mangiferin is a xanthonoid present in\n                        <jats:italic>Mangifera indica<\/jats:italic>\n                        . It has been reported for a variety of pharmacological activities, including hepatoprotection. However, the major disadvantage of mangiferin is its reduced biological activity due to poor absorption, low bioavailability and rapid elimination from the body after administration. The aim of this study was to prepare a phospholipid complex of mangiferin to overcome these limitations and to investigate the impact of the complex on hepatoprotective activity and bioavailability\n                      <\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        The results showed that the complex has an enhanced hepatoprotective and\n                        <jats:italic>in vivo<\/jats:italic>\n                        antioxidant activity as compared to pure mangiferin at the same dose level (30 and 60\u2009mg\u2009kg\n                        <jats:sup>\u22121<\/jats:sup>\n                        ). The complex restored the levels of serum hepatic marker enzymes and liver antioxidant enzymes with respect to carbon tetrachloride\u2010treated animals. The complex also increased the bioavailability of mangiferin in rat serum by 9.75\u2010fold compared to pure mangiferin at the same dose level and enhanced the elimination half\u2010life (\n                        <jats:italic>t<\/jats:italic>\n                        <jats:sub>1\/2 el<\/jats:sub>\n                        ) from 1.71\u2009\u00b1\u20090.12\u2009h\n                        <jats:sup>\u22121<\/jats:sup>\n                        to 3.52\u2009\u00b1\u20090.27\u2009h\n                        <jats:sup>\u22121<\/jats:sup>\n                      <\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        The results suggested that the complexation of mangiferin with soya phospholipid enhanced the hepatoprotection and\n                        <jats:italic>in vivo<\/jats:italic>\n                        antioxidant activity, which may be due to the improved bioavailability and pharmacokinetics of mangiferin in rat serum. \u00a9 2013 Society of Chemical Industry\n                      <\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.6422","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:13:53Z","timestamp":1381526033000},"page":"1380-1388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics"],"prefix":"10.1002","volume":"94","author":[{"given":"Sauvik","family":"Bhattacharyya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Natural Product Studies Jadavpur University Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sk Milan","family":"Ahmmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Natural Product Studies Jadavpur University Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishnu Pada","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Natural Product Studies Jadavpur University Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulok K","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Natural Product Studies Jadavpur University Kolkata 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.01.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.72"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.596"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2005.27.8.928308"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.201"},{"issue":"199","key":"e_1_2_6_7_1","first-page":"443","article-title":"Antitumor, immunomodulatory and anti\u2010HIV effect of mangiferin: a naturally occurring glucosylxanthone","volume":"42","author":"Guha S","journal-title":"Chemotherapy"},{"key":"e_1_2_6_8_1","unstructured":"YoshimiN MatsunagaK KatayamaM YamadaY KunoT QiaoZ et al. The inhibitory effects of mangiferin"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"a naturally occurring lucosylxanthone in bowel carcinogenesis of male F344 rats.Cancer Lett163:163\u2013170 (2001).","DOI":"10.1016\/S0304-3835(00)00678-9"},{"key":"e_1_2_6_9_1","volume-title":"Medicinal Plants of Philippines","author":"Quisumbing E"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf011064b"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90082-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(94)90202-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90128-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90050-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.10.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.11.018"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.07.019"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.3777"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8037105"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.9.0009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9282-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.09.025"},{"key":"e_1_2_6_23_1","first-page":"84","article-title":"Enhanced therapeutic benefit of\u2009quercetin\u2013phospholipid complex in carbon tetrachloride\u2010induced acute liver injury in rats a comparative study","volume":"4","author":"Maiti K","year":"2005","journal-title":"Iran J Pharmacol Ther"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.7.4.322"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0021-9258(18)74392-5","article-title":"The determination of bilirubin with the photoelectric colorimeter","volume":"119","author":"Malloy HT","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folins phenol reagent","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_6_29_1","first-page":"158","article-title":"Studies on the quantitative and qualitative characterisation of erythrocyte\u2009glutathione peroxidase","volume":"70","author":"Paglia DE","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(81)90272-2"},{"key":"e_1_2_6_32_1","first-page":"130","article-title":"Modified spectrophotometer assay of SOD","volume":"21","author":"Kakkar B","year":"1984","journal-title":"Ind J Biochem Biophys"},{"key":"e_1_2_6_33_1","first-page":"130","article-title":"A spectrophotometric method for measuring breakdown of hydrogen peroxide by\u2009catalase","volume":"115","author":"Beers RF","year":"1952","journal-title":"J Biol Chem"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.03.021"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960420"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.60.315"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.316"},{"key":"e_1_2_6_39_1","first-page":"614","article-title":"Plasma concentrations of free and conjugated silybin after oral intake of a silybin\u2013phosphatidylcholine complex (silipide) in healthy volunteers","volume":"32","author":"Gatti G","year":"1994","journal-title":"Int J Clin Pharmacol Ther"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-013-9991-8"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.03.034"},{"key":"e_1_2_6_42_1","first-page":"329","article-title":"Value added herbal drug delivery systems: perspectives and developments","volume":"43","author":"Mukherjee PK","year":"2009","journal-title":"Indian J Pharm Educ Res"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsfa.6422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.6422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:16:40Z","timestamp":1760869000000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.6422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,31]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/jsfa.6422"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.6422","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,31]]},"assertion":[{"value":"2013-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}