{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:22:44Z","timestamp":1785007364503,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:bold><jats:italic>Garcinia atroviridis<\/jats:italic> is a seasonal fruit plant found in many parts of South East Asia. The fruit rind is used in cooking and traditionally consumed for various reasons, including to lower blood cholesterol. A comparative study was undertaken to investigate the influence of extraction solvents and plant parts used on the lipid\u2010lowering and antioxidant activities of <jats:italic>Garcinia atroviridis<\/jats:italic>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:bold>Aqueous extracts showed better antihyperlipidemic activity than the methanol extracts. Aqueous extract of ripe fruit showed the most potent antihyperlipidemic activity, comparable to that of atorvastatin. It significantly reduced the total cholesterol (<jats:italic>P<\/jats:italic> &lt; 0.05), triglycerides (<jats:italic>P<\/jats:italic> &lt; 0.01), low\u2010density lipoprotein (<jats:italic>P<\/jats:italic> &lt; 0.01), very\u2010low\u2010density lipoprotein (<jats:italic>P<\/jats:italic> &lt; 0.01) and atherogenic index (<jats:italic>P<\/jats:italic> &lt; 0.01). In contrast, antioxidant activities of methanol extracts of all parts of <jats:italic>G. atroviridis<\/jats:italic> were higher than their respective aqueous extracts, whereby the stem and leaves extracts showed better antioxidant activities than the fruits.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:bold>Aqueous and methanol extracts of <jats:italic>G. atroviridis<\/jats:italic> showed higher antihyperlipidemic and antioxidant effects, respectively. Total phenolic and flavonoid contents showed significant correlations with antioxidant but not with antihyperlipidemic activities, indicating the involvement of other compounds. Contrary to the traditional belief, the present findings suggest that the fruit has higher antihyperlipidemic potential than the fruit rind. \u00a9 2013 Society of Chemical Industry<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6456","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T12:58:59Z","timestamp":1382619539000},"page":"1552-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects of <i>Garcinia atroviridis<\/i>: a comparative study"],"prefix":"10.1002","volume":"94","author":[{"given":"Majed Ahmed","family":"Al\u2010Mansoub","sequence":"first","affiliation":[{"name":"Discipline of Pharmacology, School of Pharmaceutical Sciences Universiti Sains Malaysia 11800 Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd. Zaini","family":"Asmawi","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, School of Pharmaceutical Sciences Universiti Sains Malaysia 11800 Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikneswaran","family":"Murugaiyah","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, School of Pharmaceutical Sciences Universiti Sains Malaysia 11800 Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization Cardiovascular diseases (CVDs)(2013). [Online]. 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