{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:57:49Z","timestamp":1772150269156,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Synthetic preservatives have been consistently used to maintain the quality of food products. However, the degree of danger to human health cannot be ignored. In this study, the antimicrobial activities of <jats:italic>Citrullus colocynthis<\/jats:italic> fruits and 4\u2010methylquinoline analogues were investigated to develop natural preservatives against foodborne bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Antimicrobial activities of the methanol extract and five fractions derived from <jats:italic>C. colocynthis<\/jats:italic> fruits were evaluated against five foodborne bacteria. The chloroform fraction possessed strong activities against five foodborne bacteria. 4\u2010Methylquinoline was isolated by chromatographic analyses. To establish the structure\u2013activity relationships, the antimicrobial activities of 4\u2010methylquinoline analogues (2\u2010hydroxyquinoline, 4\u2010hydroxyquinoline, 6\u2010hydroxyquinoline, 2\u2010methylquinoline, 6\u2010methyquinoline, 8\u2010methylquinoline and 2\u2010methyl\u20108\u2010hydroxyquinoline) were tested against food\u2010borne bacteria. When employing the agar diffusion method, 2\u2010methyl\u20108\u2010hydroxyquinoline was found to have potent activities against the five foodborne bacteria. In terms of minimum bactericidal concentration or minimum inhibitory concentration, 2\u2010methyl\u20108\u2010hydroxyquinoline had significantly higher antimicrobial activity against the five foodborne bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:italic>Citrullus colocynthis<\/jats:italic> fruits and 4\u2010methylquinoline analogues could be useful for the development of eco\u2010friendly food supplemental agents and pharmaceuticals. \u00a9 2014 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6590","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T12:08:00Z","timestamp":1390306080000},"page":"2529-2533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antimicrobial potentials of active component isolated from <i>Citrullus colocynthis<\/i> fruits and structure\u2013activity relationships of its analogues against foodborne bacteria"],"prefix":"10.1002","volume":"94","author":[{"given":"Min\u2010Gi","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology Chonbuk National University Jeonju 561\u2010756 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Applied Biosciences Kyungpook National University Daegu 702\u2010701 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yeon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology Chonbuk National University Jeonju 561\u2010756 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoi\u2010Seon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology Chonbuk National University Jeonju 561\u2010756 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2754"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.11.027"},{"key":"e_1_2_5_4_1","first-page":"2321","article-title":"Phytochemical screening and antibacterial activity of Citrullus colocynthis (Linn.) 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National Committee for Clinical Laboratory Standards Wayne PA (2008)."},{"key":"e_1_2_5_13_1","unstructured":"NCCLS Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 6th International Approved Standard (M7\u2010A6). 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