{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:47:56Z","timestamp":1789548476642,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Agriculture, Food and Rural Affairs and partly Korea Food Research Institute"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:bold>Onion peel contains a high amount of quercetin, which has been reported to have anti\u2010cholesterol, antithrombotic and insulin\u2010sensitizing properties. This study aimed to elucidate the anti\u2010adipogenic effects of quercetin\u2010rich onion peel extract (<jats:styled-content style=\"fixed-case\">OPE<\/jats:styled-content>) and to compare it with commercially available quercetin using <jats:styled-content style=\"fixed-case\">3T3\u2010L1<\/jats:styled-content> preadipocytes.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:bold>Without affecting cell viability, both <jats:styled-content style=\"fixed-case\">OPE<\/jats:styled-content> and quercetin averted adipogenesis, as characterized by dose\u2010dependent decreases in intracellular triglyceride content and glycerol 3\u2010phosphate dehydrogenase activity, but the effect was more pronounced with <jats:styled-content style=\"fixed-case\">OPE<\/jats:styled-content> than with quercetin. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels of key adipogenic genes such as <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>, C\/<jats:styled-content style=\"fixed-case\">EBP<\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>, <jats:styled-content style=\"fixed-case\">FABP4<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">aP2<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content> were decreased in a dose\u2010dependent manner by both <jats:styled-content style=\"fixed-case\">OPE<\/jats:styled-content> and quercetin.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:bold>The results indicate that <jats:styled-content style=\"fixed-case\">OPE<\/jats:styled-content> treatment significantly prevents intracellular lipid accumulation via hyperactivation of genes regulating lipolysis as compared with quercetin alone. \u00a9 2014 Society of Chemical Industry<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6604","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T09:41:56Z","timestamp":1391679716000},"page":"2655-2660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Quercetin\u2010rich onion peel extract suppresses adipogenesis by down\u2010regulating adipogenic transcription factors and gene expression in <scp>3T3\u2010L1<\/scp> adipocytes"],"prefix":"10.1002","volume":"94","author":[{"given":"Cho\u2010Rong","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Food Science and Human Nutrition, and Research Institute of Humans Ecology Chonbuk National University 567 Baekje\u2010daero deokjin\u2010gu, Jeonju\u2010si Jeollabuk\u2010do 561\u2010756 Republic of 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