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The present study was convened to assess the effects of dietary clove bud powder (<jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content>) on biochemical parameters in a type 2 diabetes rat model, induced by a combination of high\u2010fat diet and low\u2010dose streptozotocin (35 mg kg<jats:sup>\u22121<\/jats:sup>) for 30 days<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:bold>Diabetic rats were placed on dietary regimen containing 20\u201340 g kg<jats:sup>\u22121<\/jats:sup> clove bud powder. The results revealed that there was no significant (<jats:italic>P<\/jats:italic> &gt; 0.05) difference in the average feed intake and weight changes between the rat groups. Furthermore, supplementation with <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content> gradually reduced blood glucose level in diabetic rat compared to control diabetic rats without <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content> supplementation (<jats:styled-content style=\"fixed-case\">DBC<\/jats:styled-content>). Moreover, reduced activity of \u03b1\u2010glucosidase was observed in <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content> and metformin\u2010treated rat groups when compared to that of the <jats:styled-content style=\"fixed-case\">DBC<\/jats:styled-content> rat group. In addition, the <jats:styled-content style=\"fixed-case\">DBC<\/jats:styled-content> group had significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) higher lipid concentrations (except for high\u2010density lipoprotein cholesterol) when compared to all other groups. Furthermore, <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content> had significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) reduced activity of liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and showed elevated levels of antioxidant status (glutathione, ascorbic acid, superoxide dismutase and catalase)<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:bold>The results suggest that the clove bud diet may attenuate hyperglycemia, hyperlipidemia, hepatotoxicity and oxidative stress in the type 2 diabetic condition. \u00a9 2014 Society of Chemical Industry<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6617","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T05:28:08Z","timestamp":1392614888000},"page":"2726-2737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (<i>Szyzgium aromaticum<\/i>) bud powder in a high\u2010fat diet\/streptozotocin\u2010induced diabetes rat model"],"prefix":"10.1002","volume":"94","author":[{"given":"Stephen A","family":"Adefegha","sequence":"first","affiliation":[{"name":"Functional foods and Nutraceuticals, Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Functional foods and Nutraceuticals, Department of Biochemistry Federal 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