{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:43Z","timestamp":1786978063302,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International collaborative projects of Zhejiang province","award":["2013C24021"],"award-info":[{"award-number":["2013C24021"]}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Aflatoxins (\n AFs<\/jats:styled-content>\n ) are a group of potent mycotoxins that frequently pollute agro\u2010products and animal feeds. For complex reasons, the regulatory limits of\n AFs<\/jats:styled-content>\n differ from nation to nation. In this study, feedstuffs contaminated with various concentrations of aflatoxin\n B1<\/jats:styled-content>\n (\n AFB1<\/jats:styled-content>\n ) corresponding to\n AF<\/jats:styled-content>\n regulatory limits of major agro\u2010product importing and exporting nations were tested in Sprague\u2013Dawley rats, and the toxicological results were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n During the trial period, no poisoning behavior was observed and no animals died. No significant differences in body weight were observed between\n AFB1<\/jats:styled-content>\n \u2010contaminated and control rats. However, various negative impacts on liver and kidney functions were observed in\n AFB1<\/jats:styled-content>\n \u2010contaminated groups, and these negative impacts were positively correlated with\n AFB1<\/jats:styled-content>\n concentrations. At concentrations of 4\u201350 \u00b5g kg\n \u22121<\/jats:sup>\n ,\n AFB1<\/jats:styled-content>\n tolerance was observed for the liver after 15 days of testing, but this tolerance was not observed for the kidney.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Low concentrations of\n AFB1<\/jats:styled-content>\n still induced obvious toxicological impacts on Sprague\u2013Dawley rats, and the negative effects were aggravated by increasing the\n AFB1<\/jats:styled-content>\n dose and feeding time. Therefore strict\n AF<\/jats:styled-content>\n regulatory limits are suggested for food safety administration, especially for the low\u2010income nations with higher hepatitis B virus prevalence. \u00a9 2014 Society of Chemical Industry\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.6649","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T04:31:12Z","timestamp":1394512272000},"page":"3017-3022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of toxicological impacts on Sprague\u2013Dawley rat by successively low dose of aflatoxin\n B1<\/scp>"],"prefix":"10.1002","volume":"94","author":[{"given":"Wei","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest Control, Zhejiang Province Key Laboratory for Food Safety Institute of Quality and Standard for Agro\u2010products, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest Control, Zhejiang Province Key Laboratory for Food Safety Institute of Quality and Standard for Agro\u2010products, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Pharmaceutical Industry National (Shanghai) Center for New Drug Safety Evaluation and Research Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest Control, Zhejiang Province Key Laboratory for Food Safety Institute of Quality and Standard for Agro\u2010products, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest Control, Zhejiang Province Key Laboratory for Food Safety Institute of Quality and Standard for Agro\u2010products, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base for Zhejiang Sustainable Plant Pest Control, Zhejiang Province Key Laboratory for Food Safety Institute of Quality and Standard for Agro\u2010products, Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-083012-123702"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/jn\/123.suppl_2.289","article-title":"Contribution of nutritional sciences to food safety: control of mycotoxins","volume":"123","author":"Newberne PM","year":"1993","journal-title":"J Nutr"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-36.3.436"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(98)00112-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2005.03.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/790309"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901388"},{"key":"e_1_2_7_9_1","first-page":"489","volume-title":"Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins","author":"International Agency for Research on Cancer (IARC)","year":"1993"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.09.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.04.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.05.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.08.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045151"},{"key":"e_1_2_7_15_1","unstructured":"Ministry of Health (MOH) of the People's Republic of China The Mycotoxins Regulatory Limits on Foods. 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