{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:51:17Z","timestamp":1790877077492,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research University Grant Scheme","award":["9300362"],"award-info":[{"award-number":["9300362"]}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The aim of the current study was (i) to evaluate the bioactive potential of the leaf methanolic extract of <jats:italic>Cynometra cauliflora<\/jats:italic> L., along with its respective hexane, dichloromethane, ethyl acetate (<jats:styled-content style=\"fixed-case\">EtOAc<\/jats:styled-content>), <jats:italic>n<\/jats:italic>\u2010butanol (<jats:italic>n<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">BuOH<\/jats:styled-content>) and aqueous fractions, in inhibiting the enzymes \u03b1\u2010glucosidase, acetylcholinesterase (<jats:styled-content style=\"fixed-case\">AChE<\/jats:styled-content>) and tyrosinase as well as evaluating their antioxidant activities. (ii) In addition, in view of the limited published information regarding the metabolite profile of <jats:italic>C. cauliflora<\/jats:italic>, we further characterized the profiles of the <jats:styled-content style=\"fixed-case\">EtOAc<\/jats:styled-content> and <jats:italic>n<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">BuOH<\/jats:styled-content> fractions using liquid chromatography\u2013diode array detection\u2013electrospray ionization\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The leaf methanolic extract of <jats:italic>C. cauliflora<\/jats:italic> exhibited potent inhibition of all three enzymes and high antioxidant activity. The bioactivity was found to be concentrated in the <jats:styled-content style=\"fixed-case\">EtOAc<\/jats:styled-content> and <jats:italic>n<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">BuOH<\/jats:styled-content> fractions. A total of 18 compounds were identified in these bioactive fractions, comprising a procyanidin trimer, procyanidin tetramer, procyanidin hexamer, taxifolin pentoside, catechin, vitexin, isovitexin, kaempferol hexoside, quercetin pentoside, quercetin hexoside, apigenin\u20106\u2010<jats:italic>C<\/jats:italic>\u2010glucoside\u20108\u2010<jats:italic>C<\/jats:italic>\u2010glucoside, kaempferol\u2013coumaroyl hexoside and isorhamnetin hexoside.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results indicated that <jats:italic>C. cauliflora<\/jats:italic>, the leaves in particular, is a rich source of bioactive compounds and could be beneficial for further development of high\u2010value phytomedicinal preparations and functional food products. \u00a9 2014 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6832","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T04:25:03Z","timestamp":1406003103000},"page":"635-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Chemical profile and antiacetylcholinesterase, antityrosinase, antioxidant and \u03b1\u2010glucosidase inhibitory activity of <i>Cynometra cauliflora<\/i> L. leaves"],"prefix":"10.1002","volume":"95","author":[{"given":"Muhammad Abubakar","family":"Ado","sequence":"first","affiliation":[{"name":"Laboratory of Natural Products, Institute of Bioscience Universiti Putra Malaysia  43400 Serdang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridah","family":"Abas","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products, Institute of Bioscience Universiti Putra Malaysia  43400 Serdang Selangor 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