{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:17:45Z","timestamp":1772561865051,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Many studies have been conducted using purified prebiotics such as inulin or fructooligosaccharides (<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content>) as nutraceuticals, but there is very little information available on the prebiotic potential of raw products rich in inulin and <jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content>, such as Jerusalem artichoke (<jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>; <jats:italic>Helianthus tuberosus<\/jats:italic> L.). The present experiment aimed to evaluate the prebiotic effects of <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content> tubers in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Seventy\u2010two Wistar weanling rats divided into four groups were fed for 12 weeks on a basal diet fortified with pulverized <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content> tubers at 0 (control), 20, 40 and 60\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> levels. Enhanced cell\u2010mediated immunity in terms of skin indurations (<jats:italic>P<\/jats:italic> = 0.082) and <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+ T\u2010lymphocyte population (<jats:italic>P<\/jats:italic> = 0.002) was observed in the <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>\u2010supplemented groups compared with the control group. Blood haemoglobin (<jats:italic>P<\/jats:italic> = 0.017), glucose (<jats:italic>P<\/jats:italic> = 0.001), urea (<jats:italic>P<\/jats:italic> = 0.004) and calcium (<jats:italic>P<\/jats:italic> = 0.048) varied favourably upon inclusion of <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>. An increasing trend (<jats:italic>P<\/jats:italic> = 0.059) in the length of large intestine was apparent in the <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>\u2010fed groups. The tissue mass of caecum (<jats:italic>P<\/jats:italic> = 0.069) and colon (<jats:italic>P<\/jats:italic> = 0.003) was increased in the <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>\u2010supplemented groups, accompanied by higher (<jats:italic>P<\/jats:italic> = 0.007) caecal crypt depth. The <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and ammonia concentrations of intestinal digesta decreased and those of lactate and total volatile fatty acids increased in the <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>\u2010fed groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results suggest that <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content> had beneficial effects on immunity, blood metabolites, intestinal morphometry and hindgut fermentation of rats. \u00a9 2014 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.6873","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T11:55:09Z","timestamp":1408103709000},"page":"1689-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prebiotic potential of Jerusalem artichoke (<i>Helianthus tuberosus<\/i> L.) in 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