{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:58:03Z","timestamp":1788339483686,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>High\u2010fat diet (HFD)\u2010induced intestinal damage contributes to metabolic dysfunction and systemic inflammation. <jats:italic>Brevibacillus laterosporus<\/jats:italic>, a broad\u2010spectrum antimicrobial, has been approved as a microbial feed additive in the breeding industry and may improve intestinal health. This study investigated whether <jats:italic>B. laterosporus<\/jats:italic> BL1 enhances intestinal health in HFD\u2010fed mice. C57BL\/6 mice were fed an HFD with or without <jats:italic>B. laterosporus<\/jats:italic> BL1 supplementation for 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The findings showed that <jats:italic>B. laterosporus<\/jats:italic> BL1 reduced intestinal morphological damage, enhanced epithelial barrier integrity, and promoted mucosal repair. It also alleviated intestinal inflammation by suppressing innate immune components and pro\u2010inflammatory cytokines. In the ileum, <jats:italic>B. laterosporus<\/jats:italic> BL1 downregulated the expression of lipid transport\u2010related molecules. It altered the composition of the intestinal microbiota: the abundance of <jats:italic>Faecalibaculum<\/jats:italic> decreased in both the ileum and cecum, and the proportions of ileal norank_<jats:italic>f__Erysipelotrichaceae<\/jats:italic> and cecal <jats:italic>Lactobacillus<\/jats:italic> increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results indicated that <jats:italic>B. laterosporus<\/jats:italic> BL1 alleviated intestinal injury in HFD\u2010fed mice by improving intestinal barrier function, enhancing gut immune homeostasis, reducing intestinal lipid transport, and modulating gut microbiota composition. This raises the possibility of using <jats:italic>B. laterosporus<\/jats:italic> BL1 as a potential agent to maintain a host\u2010friendly gut environment. \u00a9 2025 Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.70019","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:03:57Z","timestamp":1755061437000},"page":"7557-7567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Brevibacillus laterosporus<\/i><scp>BL1<\/scp> improves intestinal barrier function and immune homeostasis and modulates gut microbiota in high\u2010fat diet\u2010fed mice"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4833-1468","authenticated-orcid":false,"given":"Guangying","family":"Weng","sequence":"first","affiliation":[{"name":"Institute of Animal Science Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and 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