{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:26:14Z","timestamp":1772994374475,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Ulcerative colitis is a chronic inflammatory disease affecting the colon and is supposed to be related to intestinal barrier dysfunction and gut microbiota disorders. Previous study identified the potential antioxidant effects of the peptide GFGFGGF derived from\n                      <jats:italic>Quasipaa spinosa<\/jats:italic>\n                      skin (QSP), but its other bioactive functions require further research. The aim of this study was to assess the function of QSP in a mouse model of colitis induced by dextran sodium sulfate (DSS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that QSP ameliorated the symptoms of DSS\u2010induced colitis in mice, such as weight loss, colon shortening, splenomegaly and histopathological changes. Further investigations revealed that QSP treatment suppressed the production of pro\u2010inflammatory cytokines (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , IL\u20106 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ). Results from RT\u2010qPCR and Western blot analyses demonstrated that QSP inhibited the activation of the NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B signaling pathway and reduced the mRNA levels of its downstream inflammation\u2010related genes (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , IL\u20106 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ). Meanwhile, QSP increased the mRNA level of tight junction proteins (ZO\u20101, Occludin) and adherens junction proteins (E\u2010cadherin) to maintain the integrity of the colonic barrier thus improving intestinal health. Meanwhile, QSP treatment modulated the composition of the intestinal microbiota, reversing the relative abundance of harmful and beneficial bacteria, and increased the levels of short\u2010chain fatty acids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicated that peptide GFGFGGF had a notable function in preventing colitis induced by DSS. The restoration of the gut barrier and the regulation of gut microbiota were achieved by it, and it may be a promising prebiotic for the treatment of colitis. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70025","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T14:08:54Z","timestamp":1752934134000},"page":"7743-7757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>Quasipaa spinosa<\/i>\n                    skin peptide\n                    <scp>GFGFGGF<\/scp>\n                    prevents dextran sodium sulfate\u2010induced colitis by improving the intestinal barrier and gut microbiota"],"prefix":"10.1002","volume":"105","author":[{"given":"Yingjian","family":"Su","sequence":"first","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-8445","authenticated-orcid":false,"given":"Lingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"},{"name":"Fujian Provincial Engineering Technology Research Center of Marine Functional Food  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"},{"name":"Fujian Provincial Engineering Technology Research Center of Marine Functional Food  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0940-6010","authenticated-orcid":false,"given":"Guiling","family":"Li","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"},{"name":"Fujian Provincial Engineering Technology Research Center of Marine Functional Food  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"},{"name":"Fujian Provincial Engineering Technology Research Center of Marine Functional Food  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejin","family":"Su","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University  Xiamen China"},{"name":"Fujian Jianfeng Biotechnology Co. 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