{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:09:45Z","timestamp":1781834985808,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Diabetes mellitus presents a significant global health burden, highlighting the need for safe and cost\u2010effective dietary interventions. Soluble dietary fiber (SDF) derived from sweet potato, rich in bioactive compounds, holds promise for improving glucose metabolism and gut microbiota, yet its effects on type 2 diabetes (T2D) remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The present study investigated the impact of different doses of sweet potato\u2010derived SDF\u2010high (SDF\u2010H, 1000\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight), SDF\u2010medium (SDF\u2010M, 600\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight) and SDF\u2010low (SDF\u2010L, 200\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight) on T2D mice over 10\u2009weeks. The results demonstrated that SDF supplementation significantly improved body weight, reduced excessive water intake and lowered postprandial blood glucose. Notably, high\u2010 and medium\u2010dose SDF improved glucose tolerance, reducing postprandial blood glucose by 23.76% and 17.10%, respectively, and mitigated diabetes\u2010induced damage to the liver, kidneys and pancreas. SDF also modulated lipid metabolism, decreasing serum total cholesterol and triglycerides at the same time as increasing high\u2010density lipoprotein cholesterol. Importantly, SDF, particularly at high doses, enhanced gut microbiota diversity and abundance, suppressing harmful bacteria and promoting beneficial genera such as\n                      <jats:italic>Alloprevotella<\/jats:italic>\n                      and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , at the same time as decreasing the abundance of\n                      <jats:italic>Helicobacter<\/jats:italic>\n                      . These findings suggest that sweet potato\u2010derived SDF exerts multi\u2010targeted benefits in T2D through metabolic regulation and gut microbiota modulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Sweet potato\u2010derived SDF is a promising natural agent for improving glycemic control, lipid profiles, and gut microbial balance in T2D, suggesting its potential as a dietary intervention for diabetes management, pending further validation in human studies. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70058","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T13:34:53Z","timestamp":1752932093000},"page":"8137-8148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gut 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