{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:15:23Z","timestamp":1786562123046,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The risk of non\u2010alcoholic fatty liver disease (NAFLD) has been inversely associated with whole grain consumption. 5\u2010Heptadecylresorcinol (AR\u2010C17) is a phenolic lipid present in the bran part of whole grain wheat, which has been proven to ameliorate obesity and atherosclerosis. However, whether AR\u2010C17 could alleviate NAFLD and the underlying molecular mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>AR\u2010C17 administration (150\u2009mg\/kg) significantly attenuated high\u2010fat diet (HFD)\u2010induced NAFLD in mice by reducing serum total cholesterol (TC), low\u2010density lipoprotein cholesterol (LDL\u2010C), and aspartate aminotransferase (AST) levels, accompanied by significant improvements in hepatic steatosis, inflammation, and fibrosis. Accordingly, serum metabolomics revealed distinct clustering of different treatment groups, and the pathway enrichment analyses indicated that AR\u2010C17 could significantly modulate primary bile acid biosynthesis. Hepatic target metabolomics further confirmed that AR\u2010C17 administration profoundly altered bile acid profiles. Western\u2010blot analysis showed that AR\u2010C17 treatment up\u2010regulated FXR (farnesoid X receptor) expression and inhibited the activation of NLRP3 (nucleotide\u2010binding oligomerization domain\u2010like receptor with a pyrin domain 3) inflammasome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>AR\u2010C17 mitigated the progression of NAFLD by modulating the hepatic bile acid profile and reducing systemic inflammation through FXR signaling pathway. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70060","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T10:45:01Z","timestamp":1752576301000},"page":"7944-7954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["5\u2010Heptadecylresorcinol ameliorates high\u2010fat diet induced non\u2010alcoholic fatty liver disease through modulating bile acid profile and suppressing inflammation"],"prefix":"10.1002","volume":"105","author":[{"given":"Zihui","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University) Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Hao","sequence":"additional","affiliation":[{"name":"Aviation Health Assurance and Flight Safety Research Laboratory, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-8527","authenticated-orcid":false,"given":"Ziyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University) Ministry of Education  Beijing 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