{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:02:14Z","timestamp":1791475334204,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFD0902004"],"award-info":[{"award-number":["2019YFD0902004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Anserine is a bioactive and nutritional food supplement, widely used in the food health supplement, athletic nutrition, and medical fields. The aim was to investigate the mechanism of anserine in alleviating atherosclerosis. ApoE\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice were fed a high\u2010fat diet and orally administered anserine at doses of 30, 60, and 120\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u2009d\n                      <jats:sup>\u22121<\/jats:sup>\n                      for 16\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Anserine showed the effect of inhibiting the synthesis of low\u2010density lipoprotein cholesterol based on reduced Surfeit 4 (Surf4) expression levels in the liver. Anserine showed the effect of accelerating cholesterol metabolism based on increased scavenger receptor class B type (SR\u2010B1), cholesterol 7\u03b1\u2010hydroxylase (CYP7A1), cholesterol 27\u03b1\u2010hydroxylase (CYP27A1), and ATP\u2010binding cassette subfamily G member 8 (ABCG8) expression levels in the liver. Anserine exhibited the effect of inhibiting exogenous cholesterol absorption based on reduced hepatocyte nuclear factor 4 alpha (HNF\u20104\u03b1)\u2013Niemann\u2013Pick C1\u2010Like 1 (NPC1L1)\u2010\n                      <jats:italic>Gramd1b<\/jats:italic>\n                      \/\n                      <jats:italic>Gramd1c<\/jats:italic>\n                      expression levels in small intestine. Correlation analysis showed that the plaque area was positively correlated with the Surf4 and NPC1L1, and negatively correlated with CYP7A1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These results suggested that anserine might be a novel strategy to alleviate atherosclerosis by regulating lipid metabolism. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70092","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:49:46Z","timestamp":1753868986000},"page":"8574-8585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anserine alleviates atherosclerosis in\n                    <scp>ApoE<\/scp>\n                    <sup>\u2212\/\u2212<\/sup>\n                    mice by regulating lipid metabolism"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5665-2653","authenticated-orcid":false,"given":"Jing","family":"Luo","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University  Zhanjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University  Zhanjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University  Zhanjiang People's Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety  Zhanjiang People's Republic of China"},{"name":"Guangdong Province Engineering Laboratory for Marine Biological 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