{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:02:16Z","timestamp":1775055736881,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      In our previous study, we demonstrated the colitis\u2010alleviating effects of\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                      hot\u2010water extract (CA\u2010HE) in an inflammatory bowel disease mouse model. In this study, we aimed to demonstrate its potential to activate intestinal immunity\n                      <jats:italic>via<\/jats:italic>\n                      Peyer's patch (PP)\u2010mediated mechanisms and serve as a functional agent for maintaining intestinal immune homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Four\u2010week oral administration of CA\u2010HE induced no toxicological effects and significantly upregulated hematopoietic (interleukin\u20104, \u20106, and granulocyte\u2013macrophage colony\u2010stimulating factor) and immunoglobulin A (IgA)\u2010inducing (IL\u201010 and tumor growth factor\u2010\u03b2) factors derived from PPs. These immunological changes were also observed in the ileum and serum, contributing to bone marrow cell proliferation. In addition, CA\u2010HE promoted IgA production in the PPs, ileum, serum, and feces. Histological analysis further revealed an increased number and size of germinal centers. Finally, CA\u2010HE beneficially modulated the intestinal environment by increasing cecal short\u2010chain fatty acid levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate that CA\u2010HE activates the intestinal immune system\n                      <jats:italic>via<\/jats:italic>\n                      PP\u2010mediated immunomodulation. Taken together, the findings indicate that CA\u2010HE may serve as a multifunctional agent for use in functional foods or pharmaceuticals that aim to maintain intestinal immune homeostasis. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70102","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T10:20:33Z","timestamp":1753957233000},"page":"8586-8595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>In vivo<\/i>\n                    <\/scp>\n                    immunostimulatory activity of\n                    <scp>\n                      <i>Centella asiatica<\/i>\n                    <\/scp>\n                    extract on the intestinal immune system in native\n                    <scp>C3H<\/scp>\n                    \/\n                    <scp>HeN<\/scp>\n            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