{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:59:14Z","timestamp":1789099154269,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Constipation is a frequent chronic disease in the community, and osmotic laxatives can effectively alleviate symptoms. However, it is not suitable for long\u2010term use. Dietary fiber is an alternative option, with a capacity to address intestinal barrier dysfunction and sustained microbial dysbiosis.\n                      <jats:italic>Ulva lactuca<\/jats:italic>\n                      polysaccharide (ULP) is an algal fiber. It contains high alduronic acid and sulfate groups and may contribute to constipation alleviation owing to its strong water retention capabilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Administration of 0.1\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ULP to mice increased fecal water content and gastrointestinal propulsion rate. It enhanced hydrophilic interactions and restored intestinal motility\u2010related peptides; motilin, gastrin and 5\u2010hydroxytryptamine rose by 50.71%, 123.70% and 185.74%, respectively. ULP also decreased the TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      and IL\u20106 inflammatory factors by 37.8% and 49.1%, and sustained the integrity of the intestinal barrier. The 16S rRNA sequencing and metabolomics showed that ULP enhanced the enrichment of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      (7.6\u2010fold) and\n                      <jats:italic>Muribaculum<\/jats:italic>\n                      (5.4\u2010fold). It synergistically increased levels of arginine and\n                      <jats:italic>S<\/jats:italic>\n                      \u2010adenosylmethionine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>ULP alleviated constipation by water retention, microbial modulation and metabolic signaling regulation. It offers a novel, multi\u2010target strategy for constipation management. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70108","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:48:38Z","timestamp":1756727318000},"page":"8664-8676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Ulva lactuca<\/i>\n                    polysaccharides alleviate constipation in mice through repairing the intestinal barrier and regulating the gut microbiota"],"prefix":"10.1002","volume":"105","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[{"name":"School of Food Science and Technology, Dalian Polytechnic University, National Engineering Research Center of Seafood  Dalian People's Republic of 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