{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T16:14:14Z","timestamp":1777220054104,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Velvet antler has been traditionally recognized for its multifaceted health benefits, yet the underlying pharmacological mechanisms have remained poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, we employed advanced analytical techniques, including liquid chromatography\u2013mass spectrometry and gas chromatography, coupled with a\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                      model, to elucidate the active small\u2010molecule components and their associated bioactivities. Our results demonstrate that a methanol\u2010derived velvet antler extract significantly extended the lifespan of\n                      <jats:italic>C. elegans<\/jats:italic>\n                      , enhanced physical functions such as pharyngeal pumping and body bends, and protected against toxic protein aggregation in models of Parkinson's disease (\u03b1\u2010synuclein), Huntington's disease (polyQ), and Alzheimer's disease (A\u03b2). Through systematic fractionation and bioactivity\u2010guided assays, we identified stearic acid (C18:0), linoleic acid (C18:2n), and arachidonic acid (C20:4n) as key fatty acids responsible for these health\u2010promoting effects. Notably, a mixture of these three fatty acids at optimal concentrations conferred healthspan benefits and neuroprotection comparable to the complete extract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings provide novel insights into the pharmacological potential of velvet antler and highlight specific fatty acids that could serve as promising therapeutic agents for aging and neurodegenerative disorders. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70166","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:35:43Z","timestamp":1758778543000},"page":"341-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncovering key bioactive fatty acids from velvet antler extracts that promote healthspan and neuroprotection in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1002","volume":"106","author":[{"given":"Ru","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural Sciences  Changchun China"},{"name":"Jilin Provincial International Cooperation Key Laboratory for Science and Technology Innovation of Special Animal and Plants  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines Dalian Institute of Chemical Physics, Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural Sciences  Changchun China"},{"name":"Jilin Provincial International Cooperation Key Laboratory for Science and Technology Innovation of Special Animal and Plants  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines Dalian Institute of Chemical Physics, Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9449-3282","authenticated-orcid":false,"given":"Yinghua","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural Sciences  Changchun China"},{"name":"Jilin Provincial International Cooperation Key Laboratory for Science and Technology Innovation of Special Animal and Plants  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1468237"},{"key":"e_1_2_10_3_1","article-title":"Protective effects of velvet antler methanol extracts on hypoxia\u2010induced damage in Caenorhabditis elegans through HIF\u20101 and ECH\u20108 mediated lipid accumulation","volume":"16","author":"Li 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