{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:39:07Z","timestamp":1768567147524,"version":"3.49.0"},"reference-count":106,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Osteoporosis is defined by decreased bone mineral density (BMD) \u2013 a core factor for bone strength and fracture risk \u2013 with progression often exacerbated by chronic inflammation. However, the role of chicken sternum cartilage (CSC) in improving bone health and its anti\u2010inflammatory\u2010related mechanisms remain unclear. Thus, this study investigated CSC's effect on bone health and elucidated its potential anti\u2010inflammatory mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      experiments using MC3T3\u2010E1 osteoblasts showed that CSC at a concentration of 1\u2009mg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      significantly promoted the growth, differentiation, and mineralization of osteoblasts while effectively reversing the cellular damage induced by the inflammatory factor tumor necrosis factor\u2010alpha;\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiments on rats demonstrated that CSC administered at a dose of 3.33\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight significantly increased bone density from 1.0648\u2009\u00b1\u20090.04 to 1.1427\u2009\u00b1\u20090.05 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), further validating its positive effect on bone health; and in mechanism exploration via protein\u2013protein docking (with UC\u2010II, the crucial component of CSC, selected as the target), ARG10 was identified as the key site for the formation of UC\u2010II\u2010HLA\u2010DR1, UC\u2010II\u2010PD\u20101, and UC\u2010II\u2010CTLA\u20104 complexes, with hydrogen bonds and salt bridges confirmed as the primary forces involved in complex formation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study confirms that CSC improves bone health by promoting osteoblast function\n                      <jats:italic>in vitro<\/jats:italic>\n                      and increasing bone density\n                      <jats:italic>in vivo<\/jats:italic>\n                      , and clarifies its anti\u2010inflammatory mechanism, providing a novel perspective for chicken cartilage in bone health protection. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70195","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:22:24Z","timestamp":1760444544000},"page":"643-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of chicken sternum cartilage on bone mineral density and its mechanism"],"prefix":"10.1002","volume":"106","author":[{"given":"Shikun","family":"Suo","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo","family":"Dang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hira","family":"Nawazish","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, School of Food Science and Engineering Hangzhou Medical College  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lufang","family":"Yang","sequence":"additional","affiliation":[{"name":"SGS\u2013CSTC Standards Technical Services Co., Ltd. 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