{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:42:35Z","timestamp":1791067355669,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hyperlipidemia is now considered a significant concern due to changes in human dietary lifestyles. These challenges have shifted the trend toward plant\u2010based foods, as fruit parts and their extracts have shown therapeutic potential against several diseases due to their unique nutritional profile. In this study, the antihyperlipidemic activities of apple peel powder (APP) and apple pomace extract (APE) were examined in Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The results showed a significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) decline in total cholesterol (from 268.5 to 96.5\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), low\u2010density lipoprotein cholesterol (from 200 to 43.6\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and triglyceride (from 198.45 to 98.14\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and a significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) increase (from 28.2 to 34.3\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) in high\u2010density lipoprotein cholesterol was investigated. Heart histopathology revealed a significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) improvement in myocardial degenerative and necrotic changes. Alongside, T\n                      <jats:sub>4<\/jats:sub>\n                      (100\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      APE) revealed a significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) improvement in liver parameters such as alanine transaminase (ALT) and aspartate transaminase (AST), which were also reduced in T\n                      <jats:sub>1<\/jats:sub>\n                      (50\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      APP), T\n                      <jats:sub>2<\/jats:sub>\n                      (100\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      APP) and T\n                      <jats:sub>3<\/jats:sub>\n                      (50\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      APE). The highest bilirubin was noted in T\n                      <jats:sub>PC<\/jats:sub>\n                      (2.9\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), whereas T\n                      <jats:sub>4<\/jats:sub>\n                      showed the lowest values i.e., 1.5\u2009mg\u2009dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      . Furthermore, the findings for body and organ weights showed a notable decline for heart, kidney, liver, lungs and spleen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The findings of the present study demonstrated a comparable impact of APP and APE at a dose of 100\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      supplementation, which has shown antihyperlipidemic activity in rats fed a high\u2010fat diet. However, toxicological safety studies are needed to ascertain their dependent responses in humans. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70242","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T09:44:11Z","timestamp":1760089451000},"page":"1195-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of apple peel powder and pomace extract on hyperlipidemic health indices of albino\n                    <scp>Wistar<\/scp>\n                    rats"],"prefix":"10.1002","volume":"106","author":[{"given":"Adnan","family":"Amjad","sequence":"first","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-0982","authenticated-orcid":false,"given":"Muhammad","family":"Waseem","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, FA &amp; E The Islamia University  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaza Maqbl","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Faculty of Biological and Agriculture Engineering, Applied College Al\u2010Baha University  Al\u2010Baha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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