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Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cryptoxanthin (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low\u2010fat diet (LFD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), a LFD plus PSCE (0.8\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      body weight per day; LFD\u2010PSCE,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), or a high\u2010fat diet (HFD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), for 6\u2009months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD\u2010PSCE,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Changes in body weight, glucose homeostasis, serum lipid profile, pro\u2010inflammatory cytokine levels, total liver lipid content and extracellular collagen accumulation were determined. PSCE supplementation reduced body weight in 40% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), improved insulin sensitivity and glucose homeostasis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and serum lipid profile (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), decreased plasma pro\u2010inflammatory cytokine levels in 30% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and reduced liver steatosis and fibrosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                      <jats:italic>In vitro<\/jats:italic>\n                      , PSCE also reduced oxidative stress and triglyceride accumulation in 40% and 20%, respectively, in 3T3\u2010L1 adipocytes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), supporting its\n                      <jats:italic>in vivo<\/jats:italic>\n                      effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      PSCE ameliorated HFD\u2010induced metabolic dysfunction, inflammation and liver injury, suggesting persimmon byproducts represent a promising source of bioactive compounds for managing T2DM and MASLD. Further studies are needed to clarify the mechanistic and molecular role of\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010CRX, the main persimmon carotenoid, in mediating these protective effects. \u00a9 2025 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70276","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:36:43Z","timestamp":1761302203000},"page":"1299-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persimmon carotenoid extract rich in \u03b2\u2010cryptoxanthin improves glucose homeostasis and reduces liver damage in high\u2010fat\u2010diet\u2010induced type 2 diabetic 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