{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:05:00Z","timestamp":1780473900251,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Citral is an active compound of lemongrass oil which has been reported to have anti\u2010inflammatory effects. This study investigates, for the first time, the simultaneous protective effects of citral on both liver and kidney in a rat model of lipopolysaccharide (LPS)\u2010induced oxidative stress and metabolic dysfunction, a condition relevant to sepsis\u2010associated multi\u2010organ injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Male rats were divided into six groups of six animals each pretreated orally with citral (10, 20, and 40\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , body weight (b.w.)) for 7\u2009days before LPS intoxication (8\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , intraperitoneal (i.p.)). Citral significantly prevented oxidative damage induced by LPS. This was evidenced by the decrease in elevated levels of malondialdehyde (MDA) and hydrogen peroxide (H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ), restoration of the enzymatic antioxidant (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)), and non\u2010enzymatic defenses (glutathione (GSH) and thiol groups). In addition, citral improved liver and kidney function markers, as shown by decrease levels of aspartate transaminase (AST), alanine transaminase (ALT), bilirubin, urea, creatinine, and uric acid levels, and also stabilized lipid profiles. Inflammatory markers such as C\u2010reactive protein (CRP) and alkaline phosphatase (ALP) were similarly mitigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Citral gives strong protection against LPS\u2010induced hepatorenal injuries, likely mediated through its antioxidant, lipid regulatory and anti\u2010inflammatory actions. These results highlight citral's translational potential as a natural therapeutic agent for preventing or treating endotoxin\u2010mediated organ damage, suggesting promise for future clinical applications in sepsis or systemic inflammatory disorders. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70298","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:31:38Z","timestamp":1762497098000},"page":"1861-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of citral on lipopolysaccharide\u2010induced oxidative organopathy in rat"],"prefix":"10.1002","volume":"106","author":[{"given":"Amani","family":"Omrani","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010resources, Higher Institute of Biotechnology of Beja University of Jendouba  Beja 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