{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:45:41Z","timestamp":1785836741367,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Cacti, including pitaya (\n                      <jats:italic>Hylocereus<\/jats:italic>\n                      spp.), are rich in antioxidants that will undoubtedly gain importance under ongoing climate change as water resources decline. Yet the molecular basis linking composition to antioxidant function remains incompletely defined. We compared white\u2010fleshed\n                      <jats:italic>H. undatus<\/jats:italic>\n                      and red\u2010fleshed\n                      <jats:italic>H. polyrhizus<\/jats:italic>\n                      across physicochemical traits, integrating correlation, principal component analysis, and molecular docking to a human iron\u2010regulatory protein (IRP1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      White\u2010fleshed fruits were larger and heavier (length 103.4\u2009mm; width 60.2\u2009mm; weight 204.7\u2009g) than red\u2010fleshed (71.9\u2009mm; 54.5\u2009mm; 126.3\u2009g). Conversely, red\u2010fleshed fruits showed higher total soluble solids (13.47\n                      <jats:italic>vs.<\/jats:italic>\n                      9.60\u2009\u00b0Brix), total phenolics (379.7\n                      <jats:italic>vs.<\/jats:italic>\n                      183.0\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), total flavonoids (303.7\n                      <jats:italic>vs.<\/jats:italic>\n                      147.3\u2009mg\u2009L\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and antioxidant activity (52.3%\n                      <jats:italic>vs.<\/jats:italic>\n                      30.0%). Organic acids and phenolics differed by species (e.g., higher citric acid in red; higher malic acid in white). Correlations indicated that greater soluble sugars were associated with higher phenolic accumulation, consistent with the elevated antioxidant capacity of red\u2010fleshed fruit. The first two principal components explained 83.3% of the total variance (PC1\u2009=\u200968.8%, PC2\u2009=\u200914.5%) and separated samples along size\/\u00b0Brix\n                      <jats:italic>versus<\/jats:italic>\n                      phenolic\/ antioxidant axes. Docking predicted favorable binding of major acids and phenolics to IRP1, suggesting plausible antioxidant mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Findings support species\u2010specific use, with red\u2010fleshed\n                      <jats:italic>H. polyrhizus<\/jats:italic>\n                      serving as a nutrient\u2010dense source of antioxidant compounds, while white\u2010fleshed\n                      <jats:italic>H. undatus<\/jats:italic>\n                      offers advantageous pomological traits. Integrating compositional profiling with multivariate analysis and docking provides mechanistic context and practical implications for breeding, climate\u2010resilient cultivation, and industrial applications. \u00a9 2025 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70322","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:41:42Z","timestamp":1763624502000},"page":"2200-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of pomological and phytochemical characteristics in white\u2010 and red\u2010fleshed pitaya (\n                    <scp>\n                      <i>Hylocereus<\/i>\n                      spp.\n                    <\/scp>\n                    ), with molecular docking insights into key bioactive compounds"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0490-9073","authenticated-orcid":false,"given":"Kerem","family":"Mertoglu","sequence":"first","affiliation":[{"name":"Department of Horticulture, Faculty of Agriculture U\u015fak University  U\u015fak T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annik","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health Gottfried Wilhelm Leibniz University Hannover  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Zargarchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health Gottfried Wilhelm Leibniz University Hannover 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