{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:04:06Z","timestamp":1793045046805,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1300604"],"award-info":[{"award-number":["2022YFD1300604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072768"],"award-info":[{"award-number":["32072768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Aflatoxin B\n                      <jats:sub>1<\/jats:sub>\n                      (AFB\n                      <jats:sub>1<\/jats:sub>\n                      ), a potent mycotoxin frequently detected in improperly stored poultry feed, induces hepatic oxidative stress, inflammation, and growth retardation in broilers. Curcumin (CUR), a polyphenolic compound derived from\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      , exhibits strong antioxidant and anti\u2010inflammatory activities; however, its efficacy and mechanisms in mitigating AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010induced hepatotoxicity in broilers remain unclear. This study aimed to evaluate the protective effects of dietary CUR supplementation on growth performance and liver health of broilers exposed to AFB\n                      <jats:sub>1<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 720 broilers (eight replicates of 15 birds each per treatment) were fed a basal diet, an AFB\u2081\u2010contaminated diet (1\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), or AFB\n                      <jats:sub>1<\/jats:sub>\n                      diets supplemented with CUR (100, 300, or 500\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) for 42\u2009days. AFB\n                      <jats:sub>1<\/jats:sub>\n                      exposure significantly reduced average daily gain and increased feed conversion ratio (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas CUR supplementation \u2013 particularly 300\u2013500\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u2013 improved growth performance relative to the AFB\n                      <jats:sub>1<\/jats:sub>\n                      group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). CUR also decreased serum alanine aminotransferase and aspartate aminotransferase activities, alleviated hepatic histopathological damage, enhanced hepatic antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase), and suppressed malondialdehyde accumulation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). At the molecular level, CUR upregulated Nrf2 and its downstream antioxidant genes while downregulating NOD\u2010like receptor protein 3 (NLRP3), caspase\u20101, and interleukin\u20101\u03b2, indicating attenuation of inflammasome activation and pyroptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Dietary curcumin effectively mitigated AFB\n                      <jats:sub>1<\/jats:sub>\n                      \u2010induced hepatotoxicity and performance loss in broilers through activation of the Nrf2 antioxidant pathway and inhibition of the NLRP3 inflammasome. These findings highlight CUR as a promising natural feed additive for protecting poultry against mycotoxin\u2010induced oxidative and inflammatory damage. \u00a9 2025 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70337","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:11:31Z","timestamp":1763961091000},"page":"2280-2288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dietary curcumin alleviates aflatoxin\n                    <scp>\n                      B\n                      <sub>1<\/sub>\n                    <\/scp>\n                    \u2010induced liver injury and improves growth performance in broilers via Nrf2 activation and\n                    <scp>NLRP3<\/scp>\n                    inflammasome 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