{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:55:12Z","timestamp":1789131312217,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Polysaccharide from\n                      <jats:italic>Schisandra chinensis<\/jats:italic>\n                      (SPJ) can attenuate the progression of Alzheimer's disease (AD) by regulating changes in gut microbiota and its metabolites, but the mechanism of action is unclear. This study aimed to investigate the anti\u2010AD effects and regulatory mechanisms of SPJ in an A\u03b2\n                      <jats:sub>25\u201335<\/jats:sub>\n                      \u2010induced AD model from the perspective of the \u2018microbe\u2013gut\u2013brain\u2019 axis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The results showed that SPJ improved spatial learning memory ability, pathological changes in the hippocampal CA1 region and intestinal barrier integrity, and modulated the composition and abundance of gut microbiota in AD rats. Meanwhile, SPJ also regulated phenylalanine, tyrosine, and tryptophan biosynthesis, and linoleic acid, \u03b1\u2010linolenic acid, phenylalanine, and arachidonic acid metabolism in AD rats. Furthermore, correlation analysis revealed a correlation between gut microbes and metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In short, via the \u2018microbe\u2013gut\u2013brain\u2019 axis, SPJ ameliorates cognitive deficits, spatial memory loss, and neuroinflammation in AD rats. \u00a9 2025 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70361","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:38:14Z","timestamp":1764758294000},"page":"2625-2636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The combination of gut microbiota and metabolomics reveals the effects of polysaccharides from\n                    <i>Schisandra chinensis<\/i>\n                    on microbiota and metabolic profile in Alzheimer's disease rats"],"prefix":"10.1002","volume":"106","author":[{"given":"Xinyuan","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis College of Pharmacy and Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis College of Pharmacy and Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis College of Pharmacy and Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan 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