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Flavonoids, a diverse group of plant\u2010derived compounds, have been shown to ameliorate ethanol\u2010induced liver injury in both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    ALD models, highlighting their potential as natural therapeutic agents for ALD. However, the clinical use of flavonoids is hindered by their generally poor solubility and low oral bioavailability. To overcome these challenges, several nanotechnology\u2010based flavonoid formulations, including nanocrystals, liposomes, nanoemulsions, polymer particles, polymer micelles, and nanogels, have been developed. The efficacy of these flavonoid nanoformulations in the context of ALD remains largely unexplored. This review summarizes current knowledge of ALD, the protective effects of various flavonoids, and recent advances in flavonoid nanoformulations. It also discusses future research directions in this field. \u00a9 2026 Society of Chemical Industry.\n                  <\/jats:p>","DOI":"10.1002\/jsfa.70458","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:20:39Z","timestamp":1768821639000},"page":"5735-5750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Flavonoids in the treatment of alcohol\u2010related\n                    <scp>liver<\/scp>\n                    disease: evidence, molecular mechanisms, and challenges"],"prefix":"10.1002","volume":"106","author":[{"given":"Fang\u2010Fang","family":"Guo","sequence":"first","affiliation":[{"name":"College of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Chao","family":"Du","sequence":"additional","affiliation":[{"name":"Jinan Institute for Product Quality Inspection  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