{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:50:25Z","timestamp":1785772225024,"version":"3.56.0"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20542"],"award-info":[{"award-number":["U22A20542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1105305"],"award-info":[{"award-number":["2023YFF1105305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Apostichopus japonicus<\/jats:italic>\n                      is a traditional medicinal and culinary species, with existing anti\u2010aging research primarily focusing on its bioactive peptides. In contrast, the anti\u2010aging potential of its major polysaccharide, fucoidan (Aj\u2010FUC), remains largely unexplored. Since the intestine is a central target in the aging process and the primary site for polysaccharide interaction, this study investigates the protective effects and underlying mechanisms of Aj\u2010FUC against\n                      <jats:sc>d<\/jats:sc>\n                      \u2010galactose (\n                      <jats:sc>d<\/jats:sc>\n                      \u2010Gal)\u2010induced intestinal senescence in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Aj\u2010FUC significantly improved intestinal function, including restoration of villus structure and colon length, as well as enhancement of motility, absorption, and digestive enzyme activity. Additionally, Aj\u2010FUC ameliorated the senescence\u2010associated secretory phenotype, reduced oxidative stress levels, and downregulated mRNA expression of\n                      <jats:italic>P16<\/jats:italic>\n                      ,\n                      <jats:italic>P21<\/jats:italic>\n                      , and\n                      <jats:italic>P53<\/jats:italic>\n                      , showing strong anti\u2010aging effects. Meanwhile, Aj\u2010FUC increased mRNA and protein levels of tight junction proteins, indicating improved intestinal barrier function. Further research revealed that Aj\u2010FUC activated the Wnt\/\u03b2\u2010catenin pathway and promoted the proliferation of intestinal stem cells (ISCs). Moreover, Aj\u2010FUC remodeled the gut microbiota and enriched\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , thereby promoting ISC growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Aj\u2010FUC mitigates intestinal aging primarily by modulating the gut microbiota and subsequently promoting ISC\u2010mediated epithelial renewal via the Wnt\/\u03b2\u2010catenin pathway. These findings highlight the promise of Aj\u2010FUC as a marine\u2010based prebiotic functional food ingredient for improving intestinal health during aging. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70471","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:21:12Z","timestamp":1769152872000},"page":"3807-3819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A gut microbiota\u2013stem cell axis mediates the anti\u2010intestinal aging effect of fucoidan from\n                    <scp>\n                      <i>Apostichopus japonicus<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"106","author":[{"given":"Houyang","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering Ocean University of 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