{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:17:01Z","timestamp":1791825421532,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      High\u2010energy and high\u2010protein diets promote excessive fat deposition in broilers, increasing their susceptibility to metabolic disorders. Ferulic acid (FA) is a phenolic acid with multiple biological functions and has potential application value. The present study evaluated the effects of dietary FA on the growth performance, lipid metabolism, bile acid synthesis and gut microbiota in broilers. In total, 640 male broilers were allocated to five groups at 1\u2009day of age, and fed with a basal diet supplemented with 0 (control group), 50, 100, 150 or 200\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      FA for 42\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      FA administration linearly and quadratically increased the average daily gain. At 42\u2009days, dietary FA linearly reduced hepatic levels of triglycerides, total cholesterol and low\u2010density lipoprotein cholesterol. It also up\u2010regulated the gene and protein expression of peroxisome proliferator\u2010activated receptor (PPAR)\u03b3 and adenosine monophosphate\u2013activated protein kinase (AMPK) in the liver. Additionally, FA enhanced the expression of CYP7A1 protein, increasing the levels of bile acids in both the liver and serum. The results of the Kruskal\u2013Wallis\n                      <jats:italic>H<\/jats:italic>\n                      test for 16S rRNA sequences indicated significant increases in\n                      <jats:italic>Blautia<\/jats:italic>\n                      and\n                      <jats:italic>Eisenbergiella<\/jats:italic>\n                      , as well as significant decreases in\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      and\n                      <jats:italic>Bacillus<\/jats:italic>\n                      . Moreover, cecal metabolomics analysis revealed differences in metabolites between the 100\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      FA and control groups, which were enriched in the signaling pathways related to lipid and amino acid metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      FA appears to enhance average daily gain, improve lipid metabolism partially by activating the AMPK\/PPAR pathway, and increase bile acid levels by activating CYP7A1. FA doses at 100\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      are recommended in commercial broilers. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70539","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:46:42Z","timestamp":1772988402000},"page":"4600-4612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the\n                    <scp>PPAR<\/scp>\n                    and\n                    <scp>CYP7A1<\/scp>\n                    pathways in broilers"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4583-4097","authenticated-orcid":false,"given":"Fei","family":"Long","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangbo","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weite","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxu","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"Han","sequence":"additional","affiliation":[{"name":"NAU\u2010Cohoo Natural Plant and Animal Health Innovation Institute  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiutong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-8078","authenticated-orcid":false,"given":"Xiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University  Nanjing China"},{"name":"NAU\u2010Cohoo Natural Plant and Animal Health Innovation Institute  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2023.100755"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2018.tb00008.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0256-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109199"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020174"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110549"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.104873"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.1873"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/3\/4\/044106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(15)30032-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad064"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491755"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2015.1992"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111305"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.976638"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.12.024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123811"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5713\/ab.23.0487"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-025-01161-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.108911"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.103700"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2022.115438"},{"key":"e_1_2_9_24_1","first-page":"116","article-title":"Dietary ferulic acid improves growth performance of broilers via enhanced intestinal antioxidant capacity and barrier function","volume":"38","author":"Hu Y","year":"2024","journal-title":"Anim Biosci"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aqrep.2024.102438"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00020-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.621339"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/542359"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00849-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.01.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175808"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c05676"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.5493"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2021.101094"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2020.05.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00804-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09964-7"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.934695"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25140-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02927-7"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12896-x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.005"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.09.024"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-023-00828-1"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-022-01138-5"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.243"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.70539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:29:48Z","timestamp":1778344188000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.70539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jsfa.70539"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.70539","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"2025-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}