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Don,\n                      <jats:italic>Helichrysum plicatum<\/jats:italic>\n                      DC.,\n                      <jats:italic>Helichrysum sanguineum<\/jats:italic>\n                      (L.) Kostel. and\n                      <jats:italic>Helichrysum stoechas<\/jats:italic>\n                      (L.) Moench. ScCO\n                      <jats:sub>2<\/jats:sub>\n                      extraction is regarded as an efficient and environmentally friendly technique for producing high\u2010quality plant extracts; however, comparative data on bioactivity and chemical composition among\n                      <jats:italic>Helichrysum<\/jats:italic>\n                      species remain limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Aerial parts of the species were collected and extracted using ScCO\n                      <jats:sub>2<\/jats:sub>\n                      at 20\u2009MPa and 40\u2009\u00b0C. The extracts were analyzed for chemical composition and phenolic profiles, and their antioxidant,\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010glucosidase inhibitory and antimicrobial activities were evaluated. The highest extraction yield was obtained from\n                      <jats:italic>H. italicum<\/jats:italic>\n                      (28.7\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), whereas\n                      <jats:italic>H. stoechas<\/jats:italic>\n                      showed the lowest yield (10.4\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). Gas chromatography\u2013mass spectrometry analysis identified (\n                      <jats:italic>Z<\/jats:italic>\n                      )\u201013\u2010octadecenal (0\u201327.11%) and 9\u2010octadecenoic acid (33.18\u201358.79%) as the dominant constituents across the species, indicating a clear prevalence of unsaturated fatty acids in ScCO\n                      <jats:sub>2<\/jats:sub>\n                      extracts. Phenolic composition varied among species, with luteolin identified as the predominant compound in all extracts.\n                      <jats:italic>Helichrysum plicatum<\/jats:italic>\n                      exhibited the highest antioxidant capacity based on 2,2'\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (i.e. ABTS)\u2022\n                      <jats:sup>+<\/jats:sup>\n                      radical scavenging activity [i.e. extract concentration providing 50% inhibition (IC\n                      <jats:sub>50<\/jats:sub>\n                      )], whereas\n                      <jats:italic>H. sanguineum<\/jats:italic>\n                      showed the strongest\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010glucosidase inhibitory activity (IC\n                      <jats:sub>50<\/jats:sub>\n                      ). Antimicrobial assays demonstrated moderate to strong inhibitory effects against both bacterial and yeast strains. Furthermore, ADMET analysis indicated favorable acute toxicity and pharmacokinetic profiles for major phytochemicals, and molecular docking revealed that luteolin, epicatechin and chlorogenic acid exhibited the most favorable binding affinities with selected target proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The results demonstrate that ScCO\n                      <jats:sub>2<\/jats:sub>\n                      extracts of\n                      <jats:italic>Helichrysum<\/jats:italic>\n                      species possess notable bioactive properties, with significant interspecific variation in chemical composition and biological activity, highlighting their potential for pharmaceutical and cosmetic applications. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70550","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:11:52Z","timestamp":1772986312000},"page":"4587-4599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical composition and bioactivity of supercritical\n                    <scp>CO<\/scp>\n                    <sub>2<\/sub>\n                    extracts of\n                    <scp>\n                      <i>Helichrysum italicum<\/i>\n                    <\/scp>\n                    ,\n                    <scp>\n                      <i>Helichrysum plicatum<\/i>\n                    <\/scp>\n                    ,\n                    <scp>\n                      <i>Helichrysum sanguineum<\/i>\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>Helichrysum stoechas<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-5377","authenticated-orcid":false,"given":"Nadire Pelin","family":"Bahadirli","sequence":"first","affiliation":[{"name":"Department of Field Crops Faculty of Agriculture, Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-3000","authenticated-orcid":false,"given":"Elif Ayse Erdogan","family":"Eliuz","sequence":"additional","affiliation":[{"name":"Department of Seafood Processing Technology Faculty of Fisheries, Mersin University  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0183","authenticated-orcid":false,"given":"Erdi Can","family":"Aytar","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Horticulture Usak University  U\u015fak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abir","family":"Nas\u0131r","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Technical Science Vocational School, Mersin University  Mersin Turkey"},{"name":"Department of Pharmacy Al\u2010Shamal Private University  Sarmad\u0101 Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_7_3_1","first-page":"150","article-title":"Adverse effects of chemical fertilizers and pesticides on human health and environment","volume":"3","author":"Kumari A","year":"2014","journal-title":"J Chem Pharm Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-009-0263-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9060423"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.09.042"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2021.105197"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-44984-1_7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123240"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0605703"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2023.e01585"},{"key":"e_1_2_7_12_1","volume-title":"Investigation of the Effect of Supercritical Carbon Dioxide Extraction on the Adsorption Capacity of Date Pits","author":"Sweidan HI","year":"2017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.24263\/2304-974X-2020-9-3-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations9100280"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5735\/085.048.0207"},{"key":"e_1_2_7_16_1","unstructured":"AksoyA Hamzao\u011fluEandBudak\u00dc T\u00fcrkiyeHelichrysumMill. 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