{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:09:54Z","timestamp":1778346594109,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Dietary aflatoxin B1 (AFB1) contamination poses a significant threat to livestock health and food safety by causing severe liver injury.\n                      <jats:sc>l<\/jats:sc>\n                      \u2010Aspartic acid (\n                      <jats:sc>l<\/jats:sc>\n                      \u2010Asp) is known for its antioxidant and anti\u2010inflammatory properties but its potential to mitigate AFB1\u2010induced hepatotoxicity and associated intestinal dysbiosis in rabbits remains unexplored. To address this, 35\u2010day\u2010old rabbits (\n                      <jats:italic>n<\/jats:italic>\n                      =\u200950) were assigned randomly to five groups: a control group, an AFB1 (0.3\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      bodyweight) group, and three groups receiving dietary\n                      <jats:sc>l<\/jats:sc>\n                      \u2010Asp supplementation (0.5%, 1.0%, or 1.5%) for 21\u2009days, with AFB1 administered during the final 5\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULT<\/jats:title>\n                    <jats:p>\n                      The results demonstrated that\n                      <jats:sc>l<\/jats:sc>\n                      \u2010Asp pretreatment significantly alleviated AFB1\u2010induced impairments in growth performance and serum biochemical parameters. It also reduced hepatic collagen fiber deposition, ameliorated ileal barrier damage, and restored the gut microbiota composition and normalized bile acid metabolism, which correlated with the regulation of key metabolic receptors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study established 1.0%\n                      <jats:sc>l<\/jats:sc>\n                      \u2010asp as an effective, gut\u2010liver axis\u2010targeted intervention against AFB1 toxicity in rabbits. This work emphasizes its nutritional potential and provides a clear rationale for future studies to elucidate its molecular mechanisms. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70557","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:11:54Z","timestamp":1773112314000},"page":"4643-4654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>l<\/scp>\n                    \u2010Aspartic acid alleviates aflatoxin\n                    <scp>B1<\/scp>\n                    \u2010induced liver injury by regulating intestinal microflora homeostasis and bile acid metabolism"],"prefix":"10.1002","volume":"106","author":[{"given":"Dejing","family":"Kong","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology  Luoyang 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