{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:10:43Z","timestamp":1780585843085,"version":"3.54.1"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860608"],"award-info":[{"award-number":["81860608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Aging is associated with chronic inflammation, oxidative stress, and metabolic disturbances. Pickled tea has been reported to demonstrate antioxidant and anti\u2010inflammatory activity; however, its effects on aging and the related mechanisms remain unclear. This study investigated whether Yunnan pickled tea could attenuate\n                      <jats:sc>d<\/jats:sc>\n                      \u2010galactose\u2010induced aging in Kunming mice. It explored the potential involvement of the microbiota\u2013gut\u2013liver\u2013brain axis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:sc>d<\/jats:sc>\n                      \u2010Galactose administration induced typical aging\u2010related alterations, including elevated inflammatory cytokines (i.e. IL\u20106 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ) in the liver and brain tissues, decreased antioxidant indicators (superoxide dismutase and glutathione), and histopathological changes in liver, jejunum, and adipose tissues. 16S rRNA sequencing showed an increased relative abundance of\n                      <jats:italic>Bacteroides vulgatus<\/jats:italic>\n                      in aging mice. Serum metabolomics revealed disturbances in amino acid and pyrimidine metabolism. Spearman correlation analysis indicated that\n                      <jats:italic>B. vulgatus<\/jats:italic>\n                      was negatively correlated with amino acids, pyrimidine metabolites, superoxide dismutase, and glutathione levels. Pickled tea intervention partially reversed these changes and reduced tissue injury. The effects were more evident than those observed with vitamin E intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Yunnan pickled tea partially alleviated\n                      <jats:sc>d<\/jats:sc>\n                      \u2010galactose\u2010induced aging\u2010related changes in mice. This may be associated with the modulation of gut microbiota composition and related metabolic pathways. These results suggest a potential role for pickled tea in the regulation of aging\u2010related processes. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70610","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:49:26Z","timestamp":1776840566000},"page":"5437-5450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Yunnan pickled tea partially mitigates\n                    <scp>d<\/scp>\n                    \u2010galactose\u2010induced aging in mice via\n                    <i>Bacteroides vulgatus<\/i>\n                    \u2010associated microbiota\u2013gut\u2013liver\u2013brain axis"],"prefix":"10.1002","volume":"106","author":[{"given":"Guihua","family":"Xie","sequence":"first","affiliation":[{"name":"College of Tea Science Yunnan Agricultural University  Kunming 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