{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:13:38Z","timestamp":1780586018463,"version":"3.54.1"},"reference-count":100,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010760","name":"Y\u00fcz\u00fcnc\u00fc Yil \u00dcniversitesi","doi-asserted-by":"publisher","award":["FYD\u20102024\u201010696"],"award-info":[{"award-number":["FYD\u20102024\u201010696"]}],"id":[{"id":"10.13039\/501100010760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles synthesized using soy lecithin from hazelnut wastes. The shell\u2010derived nanoparticles had the highest zeta potential (\u221238.62\u2009mV), and the smallest particle size and polydispersity index values. The production efficiency of nanoparticles was in the range of 79.10\u201389.46%, and the loading capacity was in the range of 38.17\u201352.59%. The antioxidant properties and thermal stability of the shell nanoparticle were higher. The highest gallic acid, rutin,\n                      <jats:italic>o<\/jats:italic>\n                      \u2010coumaric acid, quercetin and kaempferol were measured in shell nanoparticles. In the bioaccessibility results, gallic acid (69.47%), protocatechuic acid (61.28%), quercetin (61.50%) and kaempferol (52.07%) were at the highest values in the shell nanoparticle. Lipid peroxidation inhibition was highest in shell nanoparticles (8.41\u2009mg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), while the lowest effect was measured in husk nanoparticles. The order of antidiabetic activity was shell nanoparticles &gt; skin nanoparticles &gt; husk nanoparticles. The investigation revealed that the nanoparticles exhibited significant anticancer activity in the MCF\u20107 breast cancer and HT\u201029 colon cancer cell lines. Principal component analysis showed that antioxidant properties are the key drivers of principal component one (PC1), while enzyme activities influence principal component two (PC2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The results obtained revealed the potential use of nanoparticles produced from hazelnut waste (especially shell) for therapeutic purposes and prevention of diseases associated with oxidative stress. \u00a9 2026 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70615","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:40:26Z","timestamp":1774928426000},"page":"5596-5613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their\n                    <i>in vitro<\/i>\n                    anti\u2010proliferative effects in tumor cell lines"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-3023","authenticated-orcid":false,"given":"Mehmet Ali","family":"Temiz","sequence":"first","affiliation":[{"name":"Kamil Ozdag Science Faculty, Department of Biology Karamano\u011flu Mehmetbey University  Karaman T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5266-8633","authenticated-orcid":false,"given":"Emine","family":"Okumus","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Department of Food Engineering Van Yuzuncu Yil University  Van T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00524C"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2022.02.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142222"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-024-01197-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-024-02635-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12107-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2022.131220"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2024.110686"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136659"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1397872"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201819666220209093443"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-018-0517-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S362418"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2023.1645"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155509"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-022-10590-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2024.e00828"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.67"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.08.064"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000528"},{"key":"e_1_2_9_24_1","first-page":"47","article-title":"Klorojenik asit y\u00fckl\u00fc PLGA nanopartik\u00fcllerinin \u00fcretimi ve antimikrobiyal etkinli\u011finin belirlenmesi","volume":"49","author":"K\u0131l\u0131n\u00e7 YB","year":"2019","journal-title":"T\u00fcrk Mikrobiyoloji Cemiyeti Dergisi"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(03)00294-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1965.16.3.144"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(98)00102-2"},{"key":"e_1_2_9_29_1","first-page":"1","article-title":"Poly(L\u2010lactide) nanoparticles reduce amphotericin B cytotoxicity and maintain its in vitro antifungal activity","volume":"14","author":"Casa DM","year":"2014","journal-title":"J Nanosci Nanotechnol"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.793009"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.02.086"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.12.054"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26157267"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132579"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2021.106976"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2023.10.012"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081654"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15889-3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.61.01.23.7538"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.71126"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194706"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2020.125796"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1515\/gps-2021-0062"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113662"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO03180A"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2021.100119"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.102135"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112331"},{"key":"e_1_2_9_50_1","article-title":"Recycling of hazelnut husk; from bio\u2010waste to phyto\u2010assisted synthesis of silver nanoparticles","volume":"8","author":"Sivri D","year":"2023","journal-title":"Chem Select"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130742"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123044"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15807"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20090558"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.07.014"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.05.142"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1590\/fst.22819"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fhfh.2021.100024"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.066"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071578"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods7070115"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-021-02057-3"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061201"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12052604"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.953867"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2024.116204"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.29278\/azd.1313235"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0168053"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2018.01.053"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.024"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13307"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.65"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2021.1953067"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020392"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100460"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2017.12.009"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2018.1462415"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071130"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.12.053"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.31254\/phyto.2019.8210"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.15421\/012105"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2019.106171"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14613"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.004"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13770"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-021-00994-8"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2020.05.020"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.06.016"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4103"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2024.70.11.13"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-024-01198-3"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12649-025-03106-5"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.4081\/ozone.2018.7800"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/14686996.2018.1444318"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S148487"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184488"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c21332"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.1c02056"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2022.104327"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.035"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104284"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.70615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:48:05Z","timestamp":1780584485000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.70615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jsfa.70615"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.70615","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}