{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:35:30Z","timestamp":1790109330947,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Acrylamide (ACR), an environmental neurotoxicant prevalent in thermally processed foods, contributes to brain injury via oxidative stress and neuroinflammation. The cumulative effects of long\u2010term low\u2010dose exposure are particularly alarming. As a traditional food ingredient, the inflorescence of\n                      <jats:italic>Coreopsis tinctoria<\/jats:italic>\n                      Nutt. is rich in polyphenolic compounds that exhibit significant anti\u2010inflammatory and antioxidant properties. This study systematically evaluated the neuroprotective potential of\n                      <jats:italic>Coreopsis tinctoria<\/jats:italic>\n                      Nutt. polyphenols (CTNP) against chronic low\u2010dose ACR exposure in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Behavioral analyses demonstrated that CTNP (0.25\u20131.00\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) significantly ameliorated ACR\u2010induced gait abnormalities and restored voluntary activity. CTNP mitigated neuronal misalignment and loss of synaptic density in the hippocampal CA1\/CA3 regions and markedly reduced serum levels of brain injury markers MBP and GFAP by 30.6% and 41.7%, respectively. Mechanistic investigations revealed that CTNP attenuated oxidative damage via activation of the Nrf2\/HO\u20101 pathway, leading to decreased brain reactive oxygen species and malondialdehyde levels while enhancing catalase, superoxide dismutase and glutathione peroxidase activities. Furthermore, CTNP suppressed MAPK pathway\u2010mediated neuroinflammation, reducing pro\u2010inflammatory factors such as COX\u20102, TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      and IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings demonstrate that CTNP, as diet\u2010derived bioactives, mitigate ACR neurotoxicity through coordinated modulation of Nrf2\/HO\u20101 antioxidant and MAPK anti\u2010inflammatory pathways, supporting their potential as a functional food component for preventing environmental toxicant\u2010associated neural damage. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70624","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:32:04Z","timestamp":1774845124000},"page":"5451-5462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Coreopsis tinctoria<\/i>\n                    Nutt. polyphenols attenuate acrylamide\u2010induced cerebral injury via dual modulation of Nrf2\/\n                    <scp>HO<\/scp>\n                    \u20101 and\n                    <scp>MAPK<\/scp>\n                    pathways"],"prefix":"10.1002","volume":"106","author":[{"given":"Haixia","family":"Han","sequence":"first","affiliation":[{"name":"College of Food Science and Pharmacy Xinjiang Agricultural University  Urumqi China"},{"name":"Xinjiang Key Laboratory of Postharvest Fruit Science and Technology  Urumqi China"},{"name":"College of Modern Industry in Chinese Herbal Medicine Xinjiang Agricultural University  Urumqi 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