{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:30Z","timestamp":1783455270084,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut\u2013skin axis remains unexplored. This study investigated the anti\u2010atopic potential of orally administered partially hydrolyzed guar gum (PHGG), a low\u2010viscosity, fermentable galactomannan enriched in low\u2010mass oligosaccharides (mannose\/galactose ratio of 1.87).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In TNF\u2010\u03b1\/IFN\u2010\u03b3\u2010stimulated HaCaT keratinocytes, PHGG (100\u2013400\u2009\u03bcg\u2009mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) suppressed IL\u20106, IL\u20108, and MCP\u20101 secretion and down\u2010regulated AD\u2010relevant mediators, including\n                      <jats:italic>TARC<\/jats:italic>\n                      ,\n                      <jats:italic>MDC<\/jats:italic>\n                      ,\n                      <jats:italic>RANTES<\/jats:italic>\n                      , and\n                      <jats:italic>TSLP<\/jats:italic>\n                      . In TNF\u2010\u03b1\u2010challenged Caco\u20102 cells, PHGG reduced IL\u20108 and MCP\u20101 and partially restored barrier\u2010associated transcripts (\n                      <jats:italic>TJP1<\/jats:italic>\n                      ,\n                      <jats:italic>TJP2<\/jats:italic>\n                      ,\n                      <jats:italic>OCLN<\/jats:italic>\n                      ,\n                      <jats:italic>CLDN1<\/jats:italic>\n                      ) and\n                      <jats:italic>MUC2<\/jats:italic>\n                      . In 2,4\u2010dinitrochlorobenzene (DNCB)\u2010induced AD BALB\/c mice, oral PHGG (100\u2013400\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u2009d\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) attenuated lesion severity, epidermal hyperplasia, collagen loss, and mast cell infiltration without adverse effects on body weight or organ weights. PHGG reduced circulating immunoglobulins and inflammatory cytokines, suppressed skin type 2 helper T\u2010cell (Th2)\u2010associated mediators, and restored colonic immune homeostasis, as evidenced by increased immunoglobulin A (IgA) and decreased interleukin 1 beta (IL\u20101\u03b2) and IL\u20106. Cecal 16S rRNA profiling revealed that PHGG shifted dysbiotic microbial signatures toward fiber\u2010responsive Bacteroidales lineages (e.g., Muribaculaceae, Alistipes, Rikenellaceae) and partially normalized community structure in beta\u2010diversity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate that oligosaccharide\u2010enriched PHGG ameliorates AD\u2010like inflammation through concurrent modulation of cutaneous immune responses, colonic mucosal immunity, and gut microbial community structure, supporting a gut\u2013skin axis mechanism. Future studies quantifying microbial metabolites are warranted to establish causal mediators of gut\u2010to\u2010skin signaling. \u00a9 2026 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70676","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:48:10Z","timestamp":1777265290000},"page":"6380-6394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral\n                    <scp>PHGG<\/scp>\n                    ameliorates atopic dermatitis\u2010like dermatitis with concurrent modulation of colonic\n                    <scp>IgA<\/scp>\n                    and cecal microbiota: implications for the gut\u2013skin axis"],"prefix":"10.1002","volume":"106","author":[{"given":"Derrick","family":"Kakooza","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Chung\u2010Ang University  Anseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Integrated Biomedical and Life Sciences Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghyun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Chung\u2010Ang University  Anseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Cheul","family":"Shin","sequence":"additional","affiliation":[{"name":"HIEMS NATURA Inc.  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