{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:33Z","timestamp":1783455273619,"version":"3.55.0"},"reference-count":78,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The prevalence of type 2 diabetes mellitus (T2DM) has been rising in recent years, prompting interest in natural plant polysaccharides for their ability to mitigate the disease. To enhance its bioactivity, a degraded polysaccharide from sweet corn cob with ultrasonic\u2010assisted enzymatic method (UE\u2010DSCCP\u2010A) was prepared, and its structure was also characterized. Furthermore, the significant alleviation effect of UE\u2010DSCCP\u2010A on T2DM has been explored and examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The results showed that UE\u2010DSCCP\u2010A was primarily composed of glucose, and with a molecular weight of 12.87\u2009kDa.\n                      <jats:italic>In vivo<\/jats:italic>\n                      experiments showed that fasting blood glucose levels in T2DM mice was effectively reduced by UE\u2010DSCCP\u2010A. Additionally, hepatic glucose metabolism could also be regulated by UE\u2010DSCCP\u2010A through phosphoenolpyruvate carboxykinase (PEPCK) and glucose\u20106\u2010phosphatase (G6Pase) expression. T2DM\u2010induced hepatic oxidative stress injury and inflammatory responses could also be regulated by UE\u2010DSCCP\u2010A through the Nrf2\/HO\u20101 and TLR4\/MyD88\/NF\u2010\u03baB pathways. Moreover, the gut microbiota in T2DM mice was positively influenced, with an increase in beneficial bacteria such as\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ,\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      ,\n                      <jats:italic>Lachnospiraceae_NK4A136_group<\/jats:italic>\n                      ,\n                      <jats:italic>Rikenellaceae_RC9_gut_group<\/jats:italic>\n                      , and\n                      <jats:italic>Alistipes<\/jats:italic>\n                      , and a decrease in\n                      <jats:italic>Romboutsia<\/jats:italic>\n                      ,\n                      <jats:italic>Desulfovibrio<\/jats:italic>\n                      , and\n                      <jats:italic>Corynebacterium_1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study provided evidence that UE\u2010DSCCP\u2010A can regulate T2DM\u2010induced liver damage and gut microbiota imbalances through the gut\u2013liver axis, and the findings may act as a reference for the application of UE\u2010DSCCP\u2010A in functional food. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70696","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:16:03Z","timestamp":1778213763000},"page":"6555-6569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010assisted degradation of polysaccharides from sweet corn cob can regulate gut microbiota and activate multiple pathways via the gut\u2013liver axis to alleviate\n                    <scp>T2DM<\/scp>\n                    in 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