{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:39Z","timestamp":1783455279197,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Sleep deprivation (SD) not only impairs the quality of sleep and leaves the body in a state of fatigue, but also exacerbates the accumulation of reactive oxygen species (ROS) in the gut, leading to intestinal barrier dysfunction. This exacerbation results in damage to the intestinal barrier and subsequently elevates the incidence of intestinal diseases. Therefore, the present study employed a treadmill\u2010based SD model to investigate the effects of\n                      <jats:italic>Schisandra chinensis<\/jats:italic>\n                      lignans on intestinal ROS levels and gut microbiota in sleep\u2010deprived mice, aiming to elucidate their potential mechanisms in ameliorating SD\u2010related pathologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Medium\u2010dose and high\u2010dose\n                      <jats:italic>Schisandra<\/jats:italic>\n                      lignans significantly reduced ROS accumulation in the jejunum and ileum and alleviated SD\u2010induced intestinal damage. The high\u2010dose group showed markedly increased mRNA expression of AMP\u2010activated protein kinase (AMPK), sirtuin 1 (SIRT1), peroxisome proliferator\u2010activated receptor gamma coactivator 1\u2010alpha (PGC\u20101\u03b1) and Bcl\u20102 in both jejunal and ileal tissues.\n                      <jats:italic>S. chisandra<\/jats:italic>\n                      lignans decreased hexanoic acid and propionic acid levels at the same time as increasing isovaleric acid, isobutyric acid, malonic acid and butyric acid concentrations, and partially restored the disrupted structure and metabolic function of the gut microbiota in sleep\u2010deprived mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Schisandra chinensis<\/jats:italic>\n                      lignans protect against SD\u2010induced intestinal injury by modulating the AMPK\/SIRT1\/PGC\u20101\u03b1 pathway, reducing intestinal ROS production, and modulating gut microbiota diversity and metabolic activity. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70706","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:29:35Z","timestamp":1778246975000},"page":"6696-6708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antagonistic effect of\n                    <scp>\n                      <i>Schisandra chinensis<\/i>\n                    <\/scp>\n                    lignans on intestinal\n                    <scp>ROS<\/scp>\n                    accumulation and gut microbiota in sleep\u2010deprived 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