{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:54Z","timestamp":1779340074682,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102443"],"award-info":[{"award-number":["32102443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Theanine, which accumulates in\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    (L.) O. Kuntze, has demonstrated strong neuroprotective effects and other health benefits that have attracted attention. This paper reviews relevant literature published during the past 5\u2009years, analyzing and summarizing studies focusing on the neuroprotective functions of theanine. By alleviating neuroinflammation, theanine exerts therapeutic effects on mental disorders caused by cumulative stress, ranging from mild sleep disturbances to depression induced by sleep deprivation. It has also demonstrated beneficial effects in delaying disease progression and promoting repair in age\u2010related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. This paper also reviews studies investigating the protective effects of theanine against organ dysfunction caused by nerve injury, as well as its synergistic effects with other phytochemical components in promoting neurological health. The potential mechanisms underlying the neuroprotective effects of theanine are considered from three perspectives: ferroptosis induced by oxidative stress in neuronal cells, the differentiation and development of neural stem cells (NSCs), and neural signal transduction pathways. Further investigations are needed to achieve a more rigorous and comprehensive understanding of theanine. \u00a9 2026 Society of Chemical Industry.\n                  <\/jats:p>","DOI":"10.1002\/jsfa.70740","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:20:03Z","timestamp":1779337203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Theanine: a phytochemical candidate for neural protection"],"prefix":"10.1002","author":[{"given":"Yongqiao","family":"Qiang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Shandong First Medical University  Jinan China"},{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianting","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Shandong First Medical University  Jinan China"},{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengtao","family":"Ming","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelan","family":"Chong","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Huang","sequence":"additional","affiliation":[{"name":"Tea Research Institute Sichuan Academy of Agricultural Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anhui","family":"Gui","sequence":"additional","affiliation":[{"name":"Fruit and Tea Research Institute Hubei Academy of Agricultural Sciences  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zia","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences National College of Business Administration and Economics (Alhamra University)  Lahore (Multan Sub\u2010Campus) Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7521-6728","authenticated-orcid":false,"given":"Hua\u2010Feng","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Shandong First Medical University  Jinan China"},{"name":"School of Pharmacy Jining Medical University  Rizhao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13024-022-00525-z","article-title":"The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE\u2010mediated ALS\/FTD","volume":"17","author":"Masrori P","year":"2022","journal-title":"Mol Neurodegener"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13020-022-00571-1","article-title":"Tea and tea drinking: 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