{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:15:07Z","timestamp":1790741707833,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013064","name":"Key Research and Development Program of Jiangxi Province","doi-asserted-by":"publisher","award":["20233BBF64003"],"award-info":[{"award-number":["20233BBF64003"]}],"id":[{"id":"10.13039\/501100013064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Camellia oleifera<\/jats:italic>\n                      Abel. oil (\n                      <jats:italic>Camellia<\/jats:italic>\n                      oil) is a premium edible woody oil traditionally utilized in East Asia for treating burns and inflammatory disorders; however, the poor bioavailability of its active phytosterols severely limits their modern application in functional foods. To overcome this limitation, this study aimed to engineer a photothermally responsive nanoplatform to enhance the bioavailability and enable the controlled release of these dietary bioactives, based on the bioactive profile of\n                      <jats:italic>Camellia<\/jats:italic>\n                      oil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Network pharmacology and molecular docking initially identified \u03b2\u2010sitosterol as a core active component of\n                      <jats:italic>Camellia<\/jats:italic>\n                      oil. Subsequently, a photothermally responsive liposomal system was engineered by co\u2010loading \u03b2\u2010sitosterol and theabrownin\u2010derived carbon quantum dots. The liposomes exhibited a high photothermal conversion efficiency of 46.6%, enabling controlled, temperature\u2010dependent cargo release.\n                      <jats:italic>In vitro<\/jats:italic>\n                      assays demonstrated potent radical\u2010scavenging capabilities (89.4% against superoxide, 82.8% for ABTS (2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid), and 58.6% for DPPH (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl)). In lipopolysaccharide\u2010stimulated RAW264.7 macrophages, the system significantly reduced intracellular reactive oxygen species levels and downregulated pro\u2010inflammatory genes (iNOS, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106), inhibiting iNOS mRNA expression by 71.6%. Furthermore, upregulation of the reparative gene CD206 indicated a functional shift toward inflammatory resolution. Transcriptomic benchmarking revealed that the system reversed inflammatory homeostasis impairment by modulating the antagonism between inflammatory and metabolic modules, a process bioinformatically predicted to be driven by the regulatory node Pparg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This work integrates natural\n                      <jats:italic>Camellia<\/jats:italic>\n                      \u2010derived bioactive components with nanotechnology to coordinate redox status and immune homeostasis, offering a novel strategy for the high\u2010value utilization of woody oil crops as functional ingredients. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70755","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:40:13Z","timestamp":1779939613000},"page":"7209-7225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>\u03b2<\/scp>\n                    \u2010Sitosterol from\n                    <scp>\n                      <i>Camellia<\/i>\n                    <\/scp>\n                    oil integrated photothermal liposomes increasing redox\u2010balanced anti\u2010inflammation in macrophages"],"prefix":"10.1002","volume":"106","author":[{"given":"Yuling","family":"Chen","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"He","sequence":"additional","affiliation":[{"name":"Ganzhou Hake Biotech Co. 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