{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:11:31Z","timestamp":1786115491705,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Senior osteoporosis (SOP) represents a significant health concern that impacts quality of life among the elderly population. Calcium supplementation is the most common treatment for those diagnosed with osteoporosis. However, the administration of inorganic calcium supplements is often associated with adverse effects, including constipation and nephrolithiasis. The fruit of\n                      <jats:italic>Rosa roxburghii<\/jats:italic>\n                      , commonly known as \u2018Ci Li\u2019 in Chinese, is both a medicine and a food. It aids in digestion, strengthens the spleen and stomach, and improves intestinal inflammation. The polysaccharides from\n                      <jats:italic>R. roxburghii<\/jats:italic>\n                      (RRFP) also exhibit activities such as enhancing immunity, managing diabetes, and regulating intestinal function. The current methods for RRFP extraction either have low extraction rates or are not conducive to scale\u2010up applications; in addition, the effect of RRFP on improving SOP is unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>RRFP with molecular weights ranging from 50 to 100\u2009kDa was enriched by ultrafiltration, and was composed of fucose, rhamnose, arabinose, galactose, glucose, xylose, and galacturonic acid. The functional groups of polysaccharides were confirmed by Fourier transform infrared spectroscopy. Scanning electron microscopy revealed that RRFP exhibited a porous morphology. Notable increases in antioxidant capacity, dry femur weight, femur bone mineral density, and femur calcium levels were observed in RRFP group rats. Protein expression of keap1 decreased while HO\u20101 and Nrf2 increased after RRFP\u2010Ca treatment. RRFP altered the composition of the intestinal microbiota in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>RRFP could enhance calcium absorption to improve SOP by activating the Nrf2\/HO\u20101 pathway and modulating the gut microbiota, especially by altering the abundance of Lachnospiraceae. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70756","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:16:17Z","timestamp":1782274577000},"page":"7151-7162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation, characterization and evaluation of polysaccharides from\n                    <scp>\n                      <i>R<\/i>\n                    <\/scp>\n                    <i>osa roxburghii<\/i>\n                    Tratt. fruit on ameliorating senior osteoporosis in rats induced by\n                    <scp>d<\/scp>\n                    \u2010galactose and low calcium diet"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-4227","authenticated-orcid":false,"given":"Yanfang","family":"Yan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Natural Products Research Center of Guizhou Province Guizhou Medical University  Guiyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Natural Products Research Center of Guizhou Province Guizhou Medical University  Guiyang PR 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