{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:11:52Z","timestamp":1786115512236,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Xinhui Chenpi (CP) is rich in polyphenols and flavonoids with excellent bioactivity, but its high\u2010value biomass utilization is restricted. Green non\u2010thermal processing can effectively maintain the structural integrity of bioactive small molecules, which is promising for the efficient valorization of CP resources. However, targeted preparation of high\u2010activity CP fractions and their\n                      <jats:italic>in vivo<\/jats:italic>\n                      antioxidant mechanisms, as well as potential targets against alcoholic fatty liver (AFL), remain poorly clarified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A high\u2010activity CP fraction (CPSU\u2010H) was selectively prepared via pulsed electric field\u2010ultrasonic synergistic extraction, ethanol polarity grading fractionation and HPD100 macroporous resin adsorption purification. CPSU\u2010H significantly reduced malondialdehyde content to 0.32\u2009\u00b1\u20090.07\u2009nmol mg protein\n                      <jats:sup>\u22121<\/jats:sup>\n                      in\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                      , and increased total superoxide dismutase, glutathione peroxidase and catalase activities to 80.35\u2009\u00b1\u20092.15, 148.73\u2009\u00b1\u20099.05 and 9.74\u2009\u00b1\u20090.52\u2009U mg protein\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively, showing strong\n                      <jats:italic>in vivo<\/jats:italic>\n                      antioxidant enhancement under non\u2010stressed conditions. CPSU\u2010H was dominated by neohesperidin and narirutin; nucleocytoplasmic transport pathway, longevity regulating pathway and nucleotide metabolism pathway were speculated to serve as the core signaling and metabolic pathways for its antioxidant enhancement. In addition, it could exert potential intervention effect on AFL through targeting proteins PTGS2, TNF, SRC, MMP9 and EGFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study realizes the directional green preparation of CPSU\u2010H and clarifies its antioxidant mechanism under non\u2010stressed conditions and AFL\u2010related target proteins. The findings support the potential development of CPSU\u2010H as natural antioxidants and functional food components, and provide a theoretical basis for high\u2010value utilization of CP biomass and extended application of synergistic non\u2010thermal processing technologies. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70758","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:25:46Z","timestamp":1780460746000},"page":"7226-7244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green synergistic non\u2010thermal processing of Xinhui Chenpi: targeted fraction screening and mechanistic elucidation of antioxidant enhancement in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1002","volume":"106","author":[{"given":"Ping","family":"Chen","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3385-089X","authenticated-orcid":false,"given":"Quancen","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-1493","authenticated-orcid":false,"given":"Siming","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety South China University of Technology  Guangzhou China"},{"name":"Yangjiang Research Institute, Guangdong Pilot Platform of Modern Agriculture and Food for Lingnan Characteristic Fruits and Vegetables Bio\u2010processing (West Guangdong), South China University of Technology  Yangjiang China"},{"name":"School of Food Science and Engineering, Green Processing Industry College for Lingnan Specialty Fruits and Vegetables, Yangjiang Tilapia Storage and Processing Engineering Technology Research Center, Guangdong Ocean University, Yangjiang Campus  Yangjiang China"},{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang Uygur Autonomous Region Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang Uygur Autonomous Region Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong Benyue Biological Technology Co., Ltd.  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