{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:15:58Z","timestamp":1786461358698,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Camellia diacylglycerol oil (CDO), produced by enzymatic glycerolysis of camellia oil, is widely consumed as a functional food ingredient; however, its cardiovascular benefits remain insufficiently characterized. This study investigated the effects of CDO on high\u2010fat diet (HFD)\u2010induced atherosclerosis and non\u2010alcoholic fatty liver disease in\n                      <jats:italic>ApoE<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice, with a particular focus on alterations in gut microbiota and metabolomic profiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Compared with the vehicle group, CDO supplementation (3 and 6\u2009mL\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) reduced aortic plaque area by approximately 50% without significantly affecting body weight in the mice. CDO treatment significantly decreased serum triglycerides (TG), total cholesterol (TC) and low\u2010density lipoprotein cholesterol, at the same time as increasing high\u2010density lipoprotein cholesterol. Notably, CDO administered at 3\u2009mL\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      demonstrated greater efficacy than camellia oil in improving TG and high\u2010density lipoprotein cholesterol levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, CDO supplementation significantly alleviated hepatic histopathological injury, reduced Oil Red O\u2010positive lipid deposition and lowered hepatic TG and TC levels compared to the vehicle group. Gut microbiota analysis revealed a decreased Firmicutes\/Bacteroidetes ratio and increased relative abundances of\n                      <jats:italic>Roseburia<\/jats:italic>\n                      and\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      in CDO\u2010treated mice. Metabolomic profiling further identified ether lipid metabolism and bile acid\u2010related pathways as potential mediators of the metabolic improvements\u2010induced by CDO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      CDO was more effective than camellia oil in mitigating HFD\u2010induced atherosclerosis and non\u2010alcoholic fatty liver disease in\n                      <jats:italic>ApoE<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice, most likely through coordinated modulation of the gut\u2013liver\u2013vascular axis. These findings support the potential of CDO as a functional food ingredient for cardiovascular risk reduction and warrant further validation in human studies. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70776","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:16:44Z","timestamp":1780575404000},"page":"7097-7108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Camellia diacylglycerol oil attenuates atherosclerosis and\n                    <scp>NAFLD<\/scp>\n                    by modulating gut microbiota and lipid metabolism in\n                    <scp>\n                      <i>ApoE<\/i>\n                    <\/scp>\n                    <sup>\n                      <i>\u2212\/\u2212<\/i>\n                    <\/sup>\n                    mice"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-2456","authenticated-orcid":false,"given":"Sihua","family":"Wang","sequence":"first","affiliation":[{"name":"Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Bioengineering Zhuhai Campus of Zunyi Medical University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Bioengineering Zhuhai Campus of Zunyi Medical University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Qin","sequence":"additional","affiliation":[{"name":"Guizhou Camellia Oil Engineering Technology Research Center  Tongren 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