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Studies have shown its potential as a medicinal herb. In this study, <jats:italic>P. crispum<\/jats:italic> leaf and stem extracts were evaluated for their antioxidant properties, protection against <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage in normal <jats:styled-content style=\"fixed-case\">3T3\u2010L1<\/jats:styled-content> cells, and the inhibition of proliferation and migration of the <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The dichloromethane extract of <jats:italic>P. crispum<\/jats:italic> exhibited the highest phenolic content (42.31 \u00b1 0.50 mg <jats:styled-content style=\"fixed-case\">GAE<\/jats:styled-content> g<jats:sup>\u22121<\/jats:sup>) and ferric reducing ability (0.360 \u00b1 0.009 mmol g<jats:sup>\u22121<\/jats:sup>) of the various extractions performed. The extract showed <jats:styled-content style=\"fixed-case\">DPPH<\/jats:styled-content> radical scavenging activity with an <jats:styled-content style=\"fixed-case\">IC<jats:sub>50<\/jats:sub><\/jats:styled-content> value of 3310.0 \u00b1 80.5 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>. Mouse fibroblasts (<jats:styled-content style=\"fixed-case\">3T3\u2010L1<\/jats:styled-content>) pre\u2010treated with 400 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup> of the extract showed 50.9% protection against <jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, suggesting its potential in cancer prevention. The extract (300 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) inhibited <jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107 cell migration by 41% \u00b1 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:italic>Petroselinum crispum<\/jats:italic> has health\u2010promoting properties with the potential to prevent oxidative stress\u2010related diseases and can be developed into functional food. \u00a9 2015 The Authors. <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.7078","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T03:28:13Z","timestamp":1421119693000},"page":"2763-2771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["<i>Petroselinum crispum<\/i> has antioxidant properties, protects against <scp>DNA<\/scp> damage and inhibits proliferation and migration of cancer cells"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-9594","authenticated-orcid":false,"given":"Esther Lai\u2010Har","family":"Tang","sequence":"first","affiliation":[{"name":"Centre for Natural Products and Drug Discovery (CENAR) and Department of Molecular Medicine, Faculty of Medicine University of Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar","family":"Rajarajeswaran","sequence":"additional","affiliation":[{"name":"Centre for Natural Products and Drug Discovery (CENAR) and Department of Molecular Medicine, Faculty of Medicine University of Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShinYee","family":"Fung","sequence":"additional","affiliation":[{"name":"Centre for Natural Products and Drug Discovery (CENAR) and Department of Molecular Medicine, Faculty of Medicine University of Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-3178","authenticated-orcid":false,"given":"MS","family":"Kanthimathi","sequence":"additional","affiliation":[{"name":"Centre for Natural Products and Drug Discovery (CENAR) and Department of Molecular Medicine, Faculty of Medicine University of Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Apiaceae (Umbelliferae)","volume":"14","author":"Menglan S","year":"2005","journal-title":"Flora of China"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.05.031"},{"key":"e_1_2_6_4_1","volume-title":"Hortus Third: A Concise Dictionary of Plants Cultivated in the United States and Canada","author":"Bailey LH","year":"1976"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf981159m"},{"key":"e_1_2_6_6_1","first-page":"223","article-title":"Folk medicines in Merzifon (Amasya, Turkey)","volume":"30","author":"Ezer N","year":"2006","journal-title":"Turk J Bot"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystemseng.2004.07.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QUAL.0000041152.24423.bb"},{"key":"e_1_2_6_10_1","first-page":"150","article-title":"Investigation of the in vitro antioxidant effect of Petroselinum crispum (Mill.) 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