{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:20:54Z","timestamp":1788524454605,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The prevalence of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is increasing year by year and it has become an important factor that endangers health. Blue mussel lipid extract (BMLE) is rich in n\u20103 polyunsaturated fatty acids (PUFAs) and astaxanthin, which has strong anti\u2010inflammatory activity and has been shown to have a good effect on type 2 diabetes, atherosclerosis, and so forth. The aim of the present study was to investigate the effect of BMLE on MASLD and its possible mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The results showed that BMLE could significantly reduce liver lipid accumulation. In BMLE group the serum levels of total cholesterol (TC), triglyceride (TG), low\u2010density lipoprotein cholesterol (LDL\u2010C), aspartate aminotransferase (AST) and liver levels of lipid synthesis proteins fatty acid synthase (FAS), acetyl\u2010CoA carboxylase (ACC), sterol regulatory element binding protein\u20101 (SREBP\u20101) and peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u03b3) were significantly lower than the corn oil (CO) group. And BMLE down\u2010regulated the NLRP3\/Caspase\u20101\/GSDMD pyroptosis pathways, reduced the serum levels of tumor necrosis factor \u03b1 (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u20106 (IL\u20106) inflammatory factors. In addition, BMLE increased gut microbiota\n                      <jats:italic>unclassified_Muribaculaceae<\/jats:italic>\n                      , and reduced\n                      <jats:italic>uncultured_Bacteroidales_bacterium<\/jats:italic>\n                      and\n                      <jats:italic>Dubosiella<\/jats:italic>\n                      in genus level.\n                      <jats:italic>Unclassified_Muribaculaceae<\/jats:italic>\n                      was negatively correlated with IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106, FAS and PPAR\u03b3.\n                      <jats:italic>Uncultured_Bacteroidales_bacterium<\/jats:italic>\n                      was positively correlated with TG, IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106, SREBP1, ACC and Caspase\u20101.\n                      <jats:italic>Dubosiella<\/jats:italic>\n                      and TC are also significantly positively correlated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>BMLE may improve MASLD by regulating fat synthesis and reducing inflammatory factors, as well as regulating gut microbiota. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70818","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:56:53Z","timestamp":1781668613000},"page":"7884-7894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blue mussel (\n                    <i>Mytilus edulis<\/i>\n                    ) lipid extract prevents metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"106","author":[{"given":"Shiyi","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Health, Qingdao University  Qingdao China"},{"name":"School of Public 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