{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:58:15Z","timestamp":1791561495507,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Celiac disease (CD) is a chronic autoimmune condition that occurs in genetically predisposed individuals when they consume gluten. The\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010gliadin peptide exacerbates the CD pathological process by inducing oxidative stress, intestinal cell damage, and apoptosis. Addressing oxidative stress in CD may offer a valuable strategy for supplementary treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Black soybean peptides (BSPs) have been shown to inhibit oxidative stress and inflammation, although the specific mechanisms are not fully understood. This study investigated the effects of BSPs on Caco\u20102 cytotoxicity induced by the\n                      <jats:italic>\u0251<\/jats:italic>\n                      \u2010gliadin peptide (p31\u201043). The p31\u201043 peptide significantly elevated reactive oxygen species (ROS) and malondialdehyde (MDA) levels in Caco\u20102 cells, disrupted the glutathione redox cycle, diminished antioxidant enzyme activity, and hampered the activation of antioxidant signaling pathways in a CD cell model. Pretreatment with BSPs inhibited the p31\u201043\u2010induced increase in Keap1 protein levels, activated antioxidant genes through Nrf2, enhanced antioxidant enzyme activity, alleviated glutathione redox cycle imbalances, promoted catalytic subunit (GCLC) and regulatory subunit (GCLM) expression, and mitigated oxidative damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Black soybean peptides enhanced antioxidant defenses and mitigated p31\u201043\u2010induced intestinal epithelial cell toxicity by modulating the Nrf2\/Keap1 pathway, providing novel evidence for dietary intervention in CD. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  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