{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:56:41Z","timestamp":1791561401531,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Alcoholic liver disease (ALD) remains a major global health burden and a leading cause of liver\u2010related morbidity. Naturally derived polysaccharides have attracted increasing attention for their potential in ALD management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In this study, a novel polysaccharide (AMP) was isolated and purified from\n                      <jats:italic>Aronia melanocarpa<\/jats:italic>\n                      . Structural characterization showed that AMP had a molecular weight of 27.5\u2009kDa, exhibited excellent thermal stability, and was primarily composed of glucose, mannose, rhamnose, glucuronic acid, and xylose. To evaluate the hepatoprotective effects of AMP, an ALD mouse model was established through chronic ethanol administration. AMP demonstrated hepatoprotective potential against alcohol\u2010induced liver injury by ameliorating hepatic damage, suppressing pro\u2010inflammatory cytokines (interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20101\u03b2 (IL\u20101\u03b2)), enhancing activities of antioxidant enzymes (superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px)) and glutathione (GSH) content, and decreasing levels of oxidative byproducts (nitric oxide (NO) and malondialdehyde (MDA)). 16S rRNA and ITS sequencing revealed that AMP effectively reversed alcohol\u2010induced gut dysbiosis. Notably, AMP not only increased beneficial bacterial families such as Bacteroidaceae and Lachnospiraceae, while decreasing the proportions of Erysipelotrichaceae and Ruminococcaceae, but also remodeled the gut mycobiome by enriching the protective fungus\n                      <jats:italic>Kazachstania<\/jats:italic>\n                      and depleting pro\u2010inflammatory fungi including\n                      <jats:italic>Mortierella<\/jats:italic>\n                      and\n                      <jats:italic>Candida<\/jats:italic>\n                      . Notably, these protective effects may be mediated through regulation of \u2018bacteria\u2013fungi\u2019 interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>AMP is a promising therapeutic agent that combines direct hepatoprotection for gut microbiota restoration. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70875","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:10:00Z","timestamp":1785553800000},"page":"8453-8466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatoprotective effects of a novel polysaccharide from\n                    <scp>\n                      <i>Aronia melanocarpa<\/i>\n                    <\/scp>\n                    against alcohol\u2010induced liver injury via gut microbiota modulation"],"prefix":"10.1002","volume":"106","author":[{"given":"Yaqing","family":"Liu","sequence":"first","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University  Changchun China"},{"name":"College of Plant Protection and Fungi, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianci","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University  Changchun China"},{"name":"College of Plant Protection and Fungi, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikun","family":"Jia","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University  Changchun China"},{"name":"College of Plant Protection and Fungi, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canghai","family":"An","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University  Changchun China"},{"name":"College of Plant Protection and Fungi, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-0333","authenticated-orcid":false,"given":"Ling","family":"Su","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University  Changchun China"},{"name":"College of Plant Protection and Fungi, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.06.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000996"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2024.06.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134809"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000924"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114489"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2025.2455954"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.01.125"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116355"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.08.058"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.101385"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128394"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2022.10.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"ZhouB LiuP YaoXet al. Hepatoprotective effects of peach gum polysaccharides against alcoholic liver injury: moderation of oxidative stress and promotion of lipid metabolism.10(2024).","DOI":"10.3389\/fnut.2023.1325450"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.04.131"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121565"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1955654"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2026.118746"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13375"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90562"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.029"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.06.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuae143"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137696"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.102938"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2022.10.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129707"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104643"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","unstructured":"WangT JiaZ AnCet al. The protective effect of Auricularia cornea var. Li. polysaccharide on alcoholic liver disease and its effect on intestinal microbiota.28:8003(2023).","DOI":"10.3390\/molecules28248003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118212"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091409"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140493"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.03.087"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1125831"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.02.011"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.034"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23560"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2025.2450475"},{"key":"e_1_2_9_41_1","first-page":"169","article-title":"Silymarin reduces paclitaxel\u2010induced lung damage via Down\u2010regulating P2X7R expression and inhibiting inflammation and apoptosis in the rats","volume":"44","author":"Celep NA","year":"2024","journal-title":"Pak Vet J"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010098"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2025.107505"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2021.04.015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.112563"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.058"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252413347"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136097"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123381"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO00182B"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132253"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127955"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.226"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.139732"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130047"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11020215"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.08.059"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.016"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.03.074"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121745"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135766"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141359"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134156"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.138752"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.01.067"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123851"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129908"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134305"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.12.083"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.106392"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141365"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.007"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.04.050"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136930"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135309"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.70280"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2026.118558"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.04.067"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.05.066"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135566"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137450"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1018557"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103191"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.90612"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.053"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.137499"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c06392"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.03.043"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2026.108848"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2026.119080"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2024.110061"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140460"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28248003"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02247"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.877280"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1086885"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01014-8"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3684"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8090891"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.1.793-801.2006"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136703"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/21501203.2023.2256761"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18597"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13020143"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106807"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jsfa.70875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.70875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:32:24Z","timestamp":1791559944000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.70875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":104,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/jsfa.70875"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.70875","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2026-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}