{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:11Z","timestamp":1785732371010,"version":"3.56.0"},"reference-count":182,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences. By combining various polymers with active herbal ingredients, these systems mimic the natural extracellular matrix and provide improved functions such as a high surface area\u2010to\u2010volume ratio, drug targeting, and controlled drug release. Preclinical studies demonstrate that phytochemical\u2010containing nanofibers have improved therapeutic profiles, including higher anti\u2010inflammatory, antioxidant, antimicrobial, and antineoplastic effects. In various biomedical applications, such as promoting tissue engineering (such as bone and nerve regeneration), limiting tumor growth, and accelerating wound closure, it was shown that nanofibers may overcome the physicochemical limitations of herbal drugs such as low solubility and bioavailability. Despite promising preclinical study results, there are significant obstacles in the way of the commercialization of herbal drug\u2010loaded nanofibers. The difficult standardization of multi\u2010component herbal extracts, stabilization drawbacks, and the absence of scalable industrial manufacturing equipment that can maintain repeatable characterization of nanofibers are some of the major obstacles, in addition to a lack of clinical trials. To navigate the clinical translation of nanofibers, interdisciplinary collaboration regarding quality control, safety, and regulatory pathways is strictly necessary due to the case\u2010by\u2010case review approach utilized by regulatory bodies such as the US Food and Drug Administration (FDA) and European Medicines Agency (EMA). This review offers a comprehensive overview of research on herbal drug\u2010loaded nanofibers and contributes a novel perspective with regulatory and clinical translational insights. \u00a9 2026 The Author(s).\n                    <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                  <\/jats:p>","DOI":"10.1002\/jsfa.70888","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:21:32Z","timestamp":1785730892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant\u2010derived active ingredients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-3091","authenticated-orcid":false,"given":"Heybet Kerem","family":"Polat","sequence":"first","affiliation":[{"name":"Republic of Turkey Ministry of Health Turkish Medicines and Medical Devices Agency  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2316-9151","authenticated-orcid":false,"given":"Yasin","family":"Turanl\u0131","sequence":"additional","affiliation":[{"name":"Republic of Turkey Ministry of Health Turkish Medicines and Medical Devices Agency  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-3025","authenticated-orcid":false,"given":"Nihat","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy Tokat Gaziosmanpa\u015fa University  Tokat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-4229","authenticated-orcid":false,"given":"Sefa","family":"G\u00f6zc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Erzincan Binali Y\u0131ld\u0131r\u0131m University  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-5495","authenticated-orcid":false,"given":"Emre","family":"Tun\u00e7el","sequence":"additional","affiliation":[{"name":"Republic of Turkey Ministry of Health Turkish Medicines and Medical Devices Agency  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-8358","authenticated-orcid":false,"given":"Hilal","family":"Bacanak","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Tokat Gaziosmanpa\u015fa University  Tokat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-326X","authenticated-orcid":false,"given":"Eren","family":"Aytekin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-010X","authenticated-orcid":false,"given":"Sedat","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy Erciyes University  Kayseri 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