{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:02:16Z","timestamp":1785211336967,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Intestinal ageing is characterized by progressive epithelial deterioration, barrier dysfunction and impaired regenerative capacity, which together contribute to age\u2010related intestinal decline. Sulfated fucans derived from\n Saccharina japonica<\/jats:italic>\n (SJ\u2010FUC) are marine polysaccharides with potential bioactivities, although their role in intestinal ageing remains unclear. This study investigated the protective effects of SJ\u2010FUC in a D\u2010galactose\u2010induced ageing mouse model.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Administration of SJ\u2010FUC significantly alleviated intestinal ageing\u2010associated phenotypes by reducing oxidative stress, suppressing senescence\u2010associated secretory phenotype\u2010related inflammatory cytokines, and downregulating the senescence markers P53, P16 and P21. Histological analysis showed marked improvement in ileal architecture and epithelial barrier integrity. SJ\u2010FUC also mitigated ageing\u2010associated regenerative decline, as indicated by increased expression of intestinal stem cell\u2010related markers Lgr5, Ascl2 and Olfm4, elevated numbers of Olfm4\u2010positive and Ki67\u2010positive cells in ileal crypts, and restoration of Wnt\/\u03b2\u2010catenin signalling. In addition, SJ\u2010FUC promoted goblet and Paneth cell differentiation. 16S rRNA sequencing further showed that SJ\u2010FUC remodelled gut microbial composition, characterized by enrichment of beneficial taxa such as\n Lactobacillus<\/jats:italic>\n and reduction of potentially detrimental bacteria including\n Bacteroides<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Sulfated fucans from\n Saccharina japonica<\/jats:italic>\n alleviate intestinal ageing by preserving epithelial integrity and restoring regenerative capacity, supporting their potential as functional marine polysaccharides for improving age\u2010related intestinal dysfunction. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.70908","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:53:36Z","timestamp":1785210816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Saccharina japonica<\/i>\n sulfated fucans alleviate intestinal ageing\u2010associated epithelial deterioration and regenerative decline"],"prefix":"10.1002","author":[{"given":"Biqian","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehua","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-7272","authenticated-orcid":false,"given":"Yaoguang","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1559-5724","authenticated-orcid":false,"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-0255","authenticated-orcid":false,"given":"Qingjuan","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering Ocean University of China Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.17621","article-title":"Enhancing Aging and Ending Ageism: JAMA Network Open Call for Papers","volume":"4","author":"Inouye SK","year":"2021","journal-title":"JAMA Netw Open"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tibs.2020.03.008","article-title":"Senescent Cells: Emerging Targets for Human Aging and Age\u2010Related Diseases","volume":"45","author":"Song S","year":"2020","journal-title":"Trends Biochem Sci"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2023.111841","article-title":"Improving intestinal inflammaging to delay aging? 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